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Visar resultat 1 - 5 av 34 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Human brain function evaluated with rCBF-SPECT : memory and pain related changes and new diagnostic possibilities in Alzheimer’s disease

    Författare :Torbjörn Sundström; Katrine Riklund; Rimma Danielsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; brain imaging; rCBF; SPECT; early diagnosis; brain atlas; HMPAO; Alzheimer´s disease; Whiplash; neuropsychological function; episodic memory; Diagnostic radiology; Diagnostisk radiologi;

    Sammanfattning : The aim of this doctoral thesis was to study the influence of memory, pain, age and education on the regional cerebral blood flow (rCBF), i.e. brain function, in early Alzheimer's disease (AD) and in chronic neck pain patients in comparison to healthy controls and in healthy elderly per se. LÄS MER

  3. 2. Towards a deeper understanding of the human brain

    Författare :Evelina Sjöstedt; Mathias Uhlén; Jan Mulder; Caroline Kampf; Elly Hol; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain; organization; RNA; classification; mapping; proteins; antibodies; Bioteknologi; Biotechnology;

    Sammanfattning : Identifying the proteome variation in different parts of the body provides fundamental molecular details, enabling further findings and mapping of tissue specific proteins. By combining quantitative transcriptomics with qualitative antibody based proteomics, the Human Protein Atlas (HPA) project aims to protein profile each human protein-coding gene. LÄS MER

  4. 3. Blood flow assessment in cerebral arteries with 4D flow magnetic resonance imaging : an automatic atlas-based approach

    Författare :Tora Dunås; Anders Eklund; Anders Wåhlin; Jan Malm; Einar Heiberg; Umeå universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Circle of Willis; 4D flow MRI; Cerebral arteries; Vascular disease; Stroke; Automatic labeling; Probabilistic atlas; Cerebral blood flow; Neuroimaging; Magnetic Resonance Imaging;

    Sammanfattning : Background: Disturbed blood flow to the brain has been associated with several neurological diseases, from stroke and vascular diseases to Alzheimer’s and cognitive decline. To determine the cerebral arterial blood flow distribution, measurements are needed in both distal and proximal arteries. LÄS MER

  5. 4. Atlas-Based Fusion of Medical Brain Images : Methods and Applications

    Författare :Roger Lundqvist; Hans Knutsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bildanalys; Bildanalys; Image analysis; Bildanalys; Computerized Image Analysis; datoriserad bildanalys;

    Sammanfattning : This thesis focuses on the development of methods for fusion of information from medical brain scans. The concept of medical image fusion refers to the process of extracting and utilising information from several scans simultaneously in the analysis and diagnosis of patients. LÄS MER

  7. 5. Computational methods for analysis and visualization of spatially resolved transcriptomes

    Författare :Jose Fernandez Navarro; Joakim Lundeberg; Martin Hemberg; KTH; []
    Nyckelord :RNA; RNA-seq; single cell; scRNA-seq; transcriptomics; spatial transcriptomics; brain; 3D; Alzheimer’s disease; Bioteknologi; Biotechnology;

    Sammanfattning : Characterizing the expression level of genes (transcriptome) in cells and tis- sues is essential for understanding the biological processes of multicellular or- ganisms. RNA sequencing (RNA-seq) has gained traction in the last decade as a powerful tool that provides an accurate quantitative representation of the transcriptome in tissues. LÄS MER