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Visar resultat 1 - 5 av 45 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Pharmacological interactions between angiotensin-converting enzyme (ACE) inhibitors, bradykinin and nitric oxide

   Författare :Karin Persson; Karl-Erik Andersson; Linköpings universitet; []
   Nyckelord :angiotensin-converting enzyme; angiotensin-converting enzyme inhibitors; atherosclerosis; bradykinin; endothelium; in vitro; nitric oxide; MEDICINE; MEDICIN;

   Sammanfattning : Cardiovascular diseases are a major cause of death in Western countries. Angiotensin-converting enzyme (ACE) is as a key enzyme in the renin-angiotensin system involved in the regulation of blood pressure, and water and electrolyte balance in the body. LÄS MER

3. 2. Cytokine induced airway hyperreactivity characterized in an in-vitro model of asthma

   Författare :Yaping Zhang; Klinisk och experimentell allergiforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicology; Farmakologi; farmakognosi; MAPK; TNF-alpha; 5-HT; Respiratory system; Andningsorganen; Pharmacological sciences; pharmacognosy; pharmacy; interleukin-1beta; hyperresponsiveness; endothelin-1; airway; bradykinin; toxikologi; farmaci;

   Sammanfattning : Asthma is a chronic disorder of the lower airways, characterized by inflammation and hyperreactivity. Pro-inflammatory cytokines like tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) are known to play important roles in the pathogenesis, but our knowledge how these cytokines contribute to the development of airway hyperreactivity is limited. LÄS MER

4. 3. Effects of Inflammatory Mediators on Pulmonary Airways

   Författare :Ofir Bachar; Klinisk och experimentell allergiforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; electric ?eld stimulation; bradykinin; airway; tumor necrosis factor a; Respiratory system; nitric oxide; Andningsorganen; Toll-like receptor; prostaglandin E2; neurotrophin; allergy;

   Sammanfattning : Chronic inflammation is together with excessive contraction of the airways key features of asthma. The aims of the thesis were to analyze the effect of inflammatory mediators on airway smooth muscle, using an in vitro model of cultured murine airways. LÄS MER

5. 4. On angiotensin II receptor type 2 receptors in the small intestine

   Författare :Sara Ewert; Göteborgs universitet; []
   Nyckelord :renin-angiotensin; angiotensin; small intestine; mucosa; epithelium; AT1; AT2; bradykinin; BK2 receptor; nitric oxide; iNOS; smooth muscle; contractility;

   Sammanfattning : The endocrine renin-angiotensin system (RAS) is important in the regulation of extracellular fluid volume and systemic blood pressure in strenuous conditions such as hypovolemia. Also present locally in peripheral tissues, all components of RAS are expressed and have been shown to modulate development, cell growth and inflammation. LÄS MER

7. 5. Tissue kallikrein: pathophysiological role in acute pancreatitis

   Författare :Mats Bläckberg; Helsingborg Kliniska Vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute pancreatitis; aprotinin; alpha-macroglobulin; alpha1-proteinase inhibitor; turn over; kinin B2 receptor; kallidin; bradykinin; Tissue kallikrein; kallistatin; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

   Sammanfattning : Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. LÄS MER