Sökning: "bosentan"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet bosentan.
1. Endothelin in the pulmonary circulation with special reference to hypoxic pulmonary vasoconstriction
Sammanfattning : A number of substances originating from the pulmonary endothelium have recently been found to be involved in the regulation of pulmonary vascular tone. Accumulating evidence suggests that endothelial dysfunction contributes to pulmonary hypertension, an important clinical problem often associated with hypoxemia. LÄS MER
2. Endothelin and nitric oxide in coronary vascular regulation with special reference to myocardial ischemia/reperfusion injury
Sammanfattning : The vascular endothelium plays an important role in the regulation of cardiovascular function by producing bioactive substances such as nitric oxide (NO) and endothelin-I (ET- 1). Recent evidence has revealed that endothelial dysfunction is closely related to myocardial ischemia/reperfusion injury. LÄS MER
3. Allergen-induced airway reactions in the pig in vivo : inflammatory mediators as targets for asthma therapy
Sammanfattning : A pig model for studies of allergen-induced airway reactions has previously been developed. These pigs are actively sensitized to Ascaris suum and challenged with this antigen in the airways under anesthesia. LÄS MER
4. The role of endothelin during myocardial ischaemia and reperfusion : pathophysiological mechanisms and interactions with nitric oxide
Sammanfattning : Acute myocardial infarction followed by reperfusion results in accelerated necrosis of irreversibly injured myocytes as well as induction of lethal injury to reversibly injured cells. Polymorphonuclear leukocytes (PMNs) are major participants in the reperfusion-initiated inflammation. LÄS MER
5. Vardenafil and methylarginines in pulmonary hypertension
Sammanfattning : Background: Pulmonary hypertension (PH) is a rare condition characterized by endothelial dysfunction and vascular remodelling, leading to increased pulmonary vascular resistance (PVR) and right ventricular heart failure. Endothelial dysfunction is associated with an imbalance between vasoconstrictor compounds, such as endothelin and thromboxane A2, and vasodilator compounds, such as prostacyclin and nitric oxide (NO). LÄS MER