Sökning: "bortezomib"

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet bortezomib.

  1. 1. New Molecular Approaches to Glioblastoma Therapy

    Författare :Sathishkumar Baskaran; Sven Nelander; Karin Forsberg Nilsson; Silvia Marino; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; GBM; ZBTB16; PLZF; Heterogeneity; Proteasome inhibitors; Bortezomib; Pterostilbene; drug combinations; Oncology; Onkologi; Biological Research on Drug Dependence; Biologisk beroendeforskning; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Glioblastoma (GBM) is the most common high-grade brain tumor diagnosed in patients who are more than 50 years of age. The standard of care treatment is surgery, followed by radiotherapy and chemotherapy. The median life expectancy of patients is only between 12 to 15 months after receiving current treatment regimes. LÄS MER

  3. 2. Identification and characterization of a proteasome deubiquitinase inhibitor

    Författare :Slavica Brnjic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The 26S proteasome has emerged as an attractive therapeutic target in the treatment of cancers. Proteasome inhibitors have been shown to selectively kill cancer cells. The FDA approval of bortezomib for the treatment of multiple myeloma and mantle cell lymphoma has clinically validated the 26S proteasome as a therapeutic target in oncology. LÄS MER

  4. 3. Effects of proteasome inhibitors on chondrogenesis and linear bone growth

    Författare :Emma Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Linear bone growth occurs at the growth plate, a thin layer of cartilage between the epiphysis and metaphysis of long bones. In the growth plate, resting/stem-like chondrocytes divide and generate the highly proliferative chondrocytes, which further differentiate into the enlarged hypertrophic form before being substituted by bone, a process called endochondral ossification. LÄS MER

  5. 4. Studies of b-AP15 : a novel inhibitor of proteasome deubiquitinase activity

    Författare :Chao Sun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Bortezomib was the first FDA approved proteasome inhibitor that was initially very successful in treatment of multiple myeloma patients but acquired resistance and adverse side-effect highly decreased patients’ quality of life. Development of 2nd generation proteasome inhibitors that could overcome these shortcomings is thus of prime medical importance. LÄS MER

  7. 5. Proteasome inhibition in the regulation of natural killer cell function and multiple myeloma cell apoptosis

    Författare :Xiaoli Feng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple myeloma (MM) is a hematologic malignancy mostly occurring in the elderly and characterized by an expansion of monoclonal plasma cells in the bone marrow and increased monoclonal immunoglobulin in plasma. The outcome of this disease has been greatly improved due to introduction of new drugs. LÄS MER