Sökning: "bone remodeling"

Visar resultat 16 - 20 av 69 avhandlingar innehållade orden bone remodeling.

  1. 16. Biological interface of bone graft substitute materials : experimental studies on interactions between biomaterials and bone cells

    Författare :Zivko Mladenovic; Maria Ransjö; Joost D de Brujin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Bone graft substitute materials are becoming more common as alternative therapy strategies when bone defects in patients need to be treated. The interaction between bone cells and biomaterials occur at the surface of the materials. A great deal is known about the importance of surface topography and physic-chemical properties of biomaterials. LÄS MER

  3. 17. Uncemented Total Hip Arthroplasty : Aspects on Bone Biology, Implant Fixation, Periprosthetic Bone Remodeling, Bone Mineral Density and Effects of Denosumab

    Författare :Andreas Nyström; Hans Mallmin; Nils Hailer; Gösta Ullmark; Jens Sörensen; Arkan Sayed-Noor; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; THA; F-PET; Denosumab; CTMA;

    Sammanfattning : Uncemented total hip arthroplasty (THA) is associated with loss of periprosthetic bone mineral density (BMD). The collum femoris preserving (CFP) stem lost 28% of proximal BMD at 2 years. LÄS MER

  4. 18. Role of tartrate-resistant acid phosphatase in bone remodeling

    Författare :Laia Mira-Pascual; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tartrate-resistant acid phosphatase is a metalloenzyme that exists as two isoforms: the monomeric TRAP 5a and the proteolytically cleaved TRAP 5b, responsible for phosphatase activity, which is highly expressed in osteoclasts (OCs). TRAP 5b has been used as a serum marker of bone resorption, as it correlates with the absolute number of OCs and with resorption markers such as CTX-I. LÄS MER

  5. 19. Development of Novel Models for Studying Osteoclasts

    Författare :Christian Thudium; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoclast; Osteopetrosis; Osteoporosis; Bone; Hematopoiesis; Gene Therapy; Mouse Models; oc oc; RANK KO;

    Sammanfattning : This thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed by adequate amounts of bone formation by osteoblasts. LÄS MER

  7. 20. Vitamin D, bone turnover markers and hCAP-18 in children with hemato-oncological diseases

    Författare :Natalja Jackmann; Per Frisk; Outi Mäkitie; Jan Gustafsson; Anna Sällfors Holmqvist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vitamin D; pediatric cancer; leukemia; bone marrow failure; hCAP-18; bone turnover markers; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Children with hemato-oncological diseases may have significant skeletal morbidities. Vitamin D is essential for the maintenance of skeletal health and may also be important for immunological functions and cancer outcomes. LÄS MER