Avancerad sökning

Visar resultat 1 - 5 av 97 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Bone Healing after implantation of bone substitute materials. Experimental studies in estrogen deficiency

   Författare :Sven Öberg; Jan Rosenquist; Ulf Lekholm; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Bone grafts; hydroxyapatite; estrogen deficiency; demineralised bone; bone formation; AAA bone; bone defect; titanium implants; resonance frequency analysis.; Kirurgi; Surgery; Kirurgi; kirurgi; Surgery;

   Sammanfattning : Bone formation and bone healing were studied in the mandible, tibia and skull bones in adult, healthy and estrogen deficient rabbits implanted with different bone substitutes.In the first study an evaluation of the differences in bone regeneration in and around solid (Alveograf *) and porous hydroxyapatite (Interpore 200*) was undertaken. LÄS MER

3. 2. Bone Regeneration with Cell-free Injectable Scaffolds

   Författare :Gry Hulsart Billström; Sune Larsson; Kenneth B Jonsson; Jöns Hilborn; Håkan Engqvist; Olle Svensson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone tissue engineering; hydrogel; computed tomography; positron emission tomography; large femoral bone defect; rat model; hydrogel; in vivo; osteogenesis; bone regeneration; 3R; single-photon emission computed tomography; bone morphogenetic protein 2; calcium phosphates; injectable; bisphosphonate;

   Sammanfattning : Bone is a remarkable multifunctional tissue with the ability to regenerate and remodel without generating any scar tissue. However, bone loss due to injury or diseases can be a great challenge and affect the patient significantly. Autologous bone grafting is commonly used throughout the world. LÄS MER

4. 3. Human embryonic stem cells for bone engineering applications

   Författare :Giuseppe Maria de Peppo; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human skeleton; bone; bone defects; bone regeneration; regenerative medicine; tissue engineering; biomaterials; scaffold; biocoral; titanium; osseointegration bioreactor; human stem cells; embryonic stem cells; mesenchymal stem cells; embryonic-derived progenitors; osteogenic differentiation; mineralization; immune response; in vitro; in vivo;

   Sammanfattning : The human skeleton represents the supporting structure of the organism and accounts for about 20 percent of the total body mass. Despite its intrinsic capacity to regenerate and self-repair, this ability is limited and repair therapies are needed in a large number of clinical cases. LÄS MER

5. 4. The Anabolic - Anti-catabolic Paradigm of Augmenting Skeletal Regeneration: A Bone Quality Perspective

   Författare :Neashan Mathavan; Avdelningen för Biomedicinsk teknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bone fracture; Fracture healing; bone quality; Bone biomechanics; bone morphogenetic protein-7; Zoledronate; skeletal regeneration;

   Sammanfattning : Successful fracture repair is a complex series of coordinated processes leading to regeneration of new bone to bridge the fracture site, remodelling of the newly formed bone and restoration of skeletal function. Disruption of these processes occurs in approximately 10% of all fractures and leads to delayed or failed healing requiring surgical interventions, increased complication rates, prolonged rehabilitation and high morbidity. LÄS MER

7. 5. Molecular and structural patterns of guided bone regeneration (GBR). Experimental studies on the role of GBR membrane and bone substitute materials

   Författare :Ibrahim Elgali; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Regenerative medicine; biomaterials; bone substitute; calcium phosphate; guided bone regeneration; membrane; strontium; bone defect; bone remodeling; inflammation; cytokines; chemokines; growth factors; gene expression; histomorphometry; in vivo;

   Sammanfattning : The mechanisms of guided bone regeneration (GBR) and bone healing with calcium phosphate (CaP) bone substitutes are not fully understood. The major aim of this thesis was to determine the relationship between the bone formation in bone defects and the cellular distribution and activities in association with CaP materials and/or with GBR membrane. LÄS MER