Sökning: "bone morphogenetic protein"
Visar resultat 6 - 10 av 45 avhandlingar innehållade orden bone morphogenetic protein.
6. Allograft bone in hip revision: the effect of locally applied pharmacological treatment
Sammanfattning : The clinical success of primary hip replacement is paramount but the need for revisions will continue to increase due to the increasing number of operated individuals. In Sweden, the number of hip revisions in 2012 exceeded 2,300. During implant loosening, some of the bone in the femur is lost, which can make the revision more difficult. LÄS MER
7. Bone Enhancement with BMP-2 for Safe Clinical Translation
Sammanfattning : Bone morphogenetic protein-2 (BMP-2) is considered a promising adjuvant for the treatment of bone regeneration. However, BMP-2 delivery in a conventional collagen scaffold needs a high dose to achieve an effective outcome. Moreover, such dosage may lead to serious side effects. LÄS MER
8. Hyaluronan Derivatives and Injectable Gels for Tissue Engineering
Sammanfattning : The present work describes the preparation of hyaluronan derivatives and hydrogels with potential use in tissue engineering applications. A potentially injectable hydrogel consisting of hyaluronan and collagen was successfully used to grow neurons in vitro by encapsulation of neural stem and progenitor cells. LÄS MER
9. Molecular regulators in cartilage and bone formation
Sammanfattning : Cartilage functions as a scaffold for bone formation during development. This process, endochondral ossification, is regulated by systemic hormones and local growth factors. LÄS MER
10. New insights into principles of scaffolds design for bone application
Sammanfattning : This thesis presents deeper insights into bone applicable biomaterials’ design. Poor affinity of BMP-2 towards scaffolds required supra-physiological dose administration. Though molecules containing sulfate could sustain BMP-2 release, side effects occurred due to BMP-2 supra-dose, or these sulfate-containing biomolecules. LÄS MER