Sökning: "bone marrow niche"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden bone marrow niche.

  1. 1. Regulation of Hematopoietic Stem and Progenitor Cells by Bone Marrow Niche Components

    Författare :Hong Qian; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cell; Hematologi; extracellular fluids; Haematology; bone marrow; Hematopoiesis; extracellulära vätskor;

    Sammanfattning : Throughout the lifespan of an individual, enormous numbers of mature blood cells are generated by hematopoietic stem cells (HSCs) in the bone marrow (BM). The HSC is a cell that can self-renew to maintain the HSC pool and differentiate into all types of mature blood cells. LÄS MER

  3. 2. Understanding the role of bone marrow niche in myeloid malignancies

    Författare :Monika Dolinska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Normal hematopoiesis is generated and maintained by rare hematopoietic stem cells (HSCs) through their capacity to self-renew and differentiate. This process is rigorously controlled, both by HSC-intrinsic molecular programs and extrinsic signals emitted by the local bone marrow (BM) microenvironment, the so-called HSC niche. LÄS MER

  4. 3. MESENCHYMAL STEM- AND STROMAL CELLS IN BONE MARROW AND OSTEOSARCOMA

    Författare :Jan Claas Brune; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mesenchymal stem cells; stromal cells; bone marrow stem cells; tumour stroma; stroma-directed anti-tumour therapy; osteosarcoma;

    Sammanfattning : Primary mesenchymal stem cells (MSC) play a central role in bone marrow (BM) and during haematopoiesis. Yet, the exact phenotype and spatial distribution of primary MSC in the human BM are unknown. Their cultured progeny are promising candidates for clinical applications. LÄS MER

  5. 4. Bone marrow mesenchymal stem and progenitor cells in myeloid malignancies

    Författare :Pingnan Xiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hematopoietic stem cells (HSCs) reside in bone marrow (BM) microenvironment / niche to self-renew and generate all types of mature blood cells in postnatal life. This process is called hematopoiesis. Normal hematopoiesis is tightly regulated by both intrinsic signaling in HSCs and extrinsic signals from BM niche. LÄS MER

  7. 5. THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate

    Författare :Matilda Rehn; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic Stem Cells; Stem Cell Niche; Hypoxia; Hypoxia-Inducible Factor; Vegfa.;

    Sammanfattning : Hematopoiesis is the process of blood formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. LÄS MER