Sökning: "blood brain barrier damage"

Visar resultat 1 - 5 av 39 avhandlingar innehållade orden blood brain barrier damage.

  1. 1. Pathophysiology of blood-brain barrier, brain edema and cell injury following hyperthermia : New role of heat shock protein, nitric oxide and carbon monoxide : an experimental study in rat using light and electron microscopy

    Författare :Hari Shanker Sharma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; blood-brain barrier; heat stress; hyperthermia; brain edema; serotonin; nitric oxide; carbon monoxide; heat shock protein; glial fibrillary acidic protein; myelin basic protein; opioids; histamine; catecholamines; naloxone; indomethacin; p-CPA; electron microscopy; immunocytochemistry; Cellbiologi; Cell biology; Cellbiologi; Human Anatomy; anatomi;

    Sammanfattning : This thesis deals with the molecular mechanisms of hyperthermia induced brain damage in rats. The results clearly establish that hyperthermia caused by 4 h heat stress at 38° C is associated with a breakdown of the blood-brain barrier (BBB) permeability which seems to be instrumental in causing brain edema and cell injury. LÄS MER

  3. 2. Effects of Mobile Phone Radiation upon the Mammalian Brain

    Författare :Henrietta Nittby; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mobile phone; electromagnetic radiation; Blood-brain barrier; brain; rat;

    Sammanfattning : oday about half of the world's population owns the microwave producing mobile phones. The blood-brain barrier (BBB) protects the mammalian brain from potentially harmful substances circulating in the blood. LÄS MER

  4. 3. Neurochemical and cognitive aftermaths of surgery - studies on short- and long-term effects of surgery and anesthesia

    Författare :Mattias Danielsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anesthesia; blood-brain barrier; brain amyloidosis; cardiac surgery; orthopedic surgery; inflammation; neuroinflammation; neuronal damage; cognitive decline; postoperative cognitive dysfunction;

    Sammanfattning : Background: Each year, around the world, more than 230 million patients have surgery. Improvements in healthcare have resulted in older and sicker patients undergoing surgical interventions. As a result, surgical safety has be-come a global public-health concern. LÄS MER

  5. 4. Cellular and molecular mechanisms of ischemic brain damage in hyperglycemic rats

    Författare :Hiroyuki Uchino; Lund Wallenberg Neurocentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Reperfusion injury; Mitochondria; Permeability transition; Cyclosporin A; Neurotrophins; Seizures; Brain damage; Acidosis; Hypercapnia; Ischemia; Hyperglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : The present study is centered on mechanisms of ischemic brain damage in hyperglycemic animals, and in those in which exaggerated intraischemic acidosis was induced by superimposed hypercapnia in normoglycemic animals. The initial experiments were focussed on the pathophysiology of postischemic seizures. LÄS MER

  7. 5. Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury

    Författare :Pernilla Svedin; Göteborgs universitet; []
    Nyckelord :hypoxia-ischemia; LPS; immature; brain; inflammation; NAC; melatonin; G-2mPE; MMP-9; MMP-12;

    Sammanfattning : Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, which makes it difficult to find effective treatment. LÄS MER