Sökning: "bisphosphonates"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet bisphosphonates.

  1. 1. Bisphosphonates for orthopedic applications. Studies in rat models

    Författare :Jörgen Åstrand; Lund Ortopedi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatology; Kirurgi; ortopedi; traumatologi; orthopaedics; Surgery; topical treatment; osteonecrosis; bone graft resorption; prosthetic loosening; Bisphosphonates; osteoclasts;

    Sammanfattning : Prosthetic loosening, bone graft resorption and osteonecrosis are examples of problems in orthopedic surgery caused by or augmented by bone resorption. Bone resorption is caused by osteoclasts. Osteoclasts can be inactivated with biphosphonates, a drug in clinical use against osteoporosis and osteolytic tumors. LÄS MER

  3. 2. Benefits and harms of Bisphosphonates : an observational study

    Författare :Jonathan Bergman; Peter Nordström; Miia Kivipelto; Håkan Melhus; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; osteoporosis; fracture; alendronate; risedronate; zoledronic acid; glucocorticoid; mortality; osteonecrosis; register; registry; real-world evidence; epidemiology; Geriatrics; geriatrik; epidemiologi; Epidemiology;

    Sammanfattning : Background: Bisphosphonates are first-line treatment for osteoporosis, but osteoporosis is considered an undertreated disease. The general aim of this dissertation was to further study the benefits and harms of bisphosphonates. LÄS MER

  4. 3. Meta-analysis of randomized clinical evidence of chemotherapy, radiotherapy and endocrine therapy in breast cancer

    Författare :Antonis Valachis; Vassilios Georgoulias; Dimitros Mavroudis; Gregory Chouverakis; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Meta -analysis; Bisphosphonates; Bevacizumab; Trastuzumab; Fulvestrant;

    Sammanfattning :  Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide. Despite the growing body of randomized controlled trials (RCTs) regarding the use of various treatment strategies (chemotherapy, endocrine therapy, radiotherapy) in breast cancer, the efficacy of some strategies remains unclear and questionable. LÄS MER

  5. 4. Evaluation of Functionalized Biopolymers as a Step Toward Targeted Therapy of Osteoporosis

    Författare :Sujit Kootala; Jöns Hilborn; Peter Thomsen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Osteoporosis; Bone regeneration; Biomaterials; Hyaluronic acid; Bisphosphonates; Osteoclasts; Osteoblasts; Growth factors; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry; Kemi med inriktning mot materialkemi; Chemistry with specialization in Materials Chemistry;

    Sammanfattning : The work presented in this thesis focuses on the development of strategies and smart bioactive materials for the treatment of osteoporosis. High and low molecular weight soluble hyaluronic acid-bisphosphonate (HA-BP) derivatives were investigated for their ability to inhibit osteoclasts. LÄS MER

  7. 5. Clinical and experimental studies of bone substitutes and dental implants in compromised bone sites

    Författare :Amela Trbakovic; Andreas Thor; Patricia Hedenqvist; Christer Dahlin; Uppsala universitet; []
    Nyckelord :clinical follow-up; calcium phosphates; rabbit model; sinus lift; radius model; in vivo; bisphosphonates; narrow diameter implants; dental implants; Oral and Maxillofacial Surgery; Käkkirurgi;

    Sammanfattning : Background: With an ageing population, an increase of more challenging implant treatments is expected. In this thesis, we evaluate the outcome of two faster implant protocols, in patients with compromised alveolar bone. LÄS MER