Sökning: "bis indole alkaloids"

Hittade 2 avhandlingar innehållade orden bis indole alkaloids.

1. 1. Synthetic studies of marine indole alkaloids and related systems

   Författare :Ann-Louise Jonsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Marine indole alkaloids; antifouling; synthesis; diketopiperazines; HWE-reaction; bis indole alkaloids; imidates; carbazole alkaloids;

   Sammanfattning : This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities. In the first part of this thesis we could establish and confirm the stucture of barettin and 8,9dihydrobarettin, isolated from the marine sponge Geodia baretti. LÄS MER

3. 2. Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds

   Författare :Hamid Shirani; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Heterocycles; indoles; 3- arylthio indoles; thiopyranobisindoles; dibenzothiepins; 3; 3′-dithiobisindoles; alkaloids; echinosulfone A; cyclization; ortho-metalation; McMurry coupling; sulfides; sulfones and disulfides;

   Sammanfattning : This thesis deals mainly with the synthesis of various sulfur/selenium-containing heterocyclic compounds, many of which include structural features present in several biologically active molecules, with particular emphasis on compounds of synthetic importance, such as indoles, as well as other heteroaromatic species. In the first part, an efficient procedure toward synthesis of new 3-(arylthio)indoles based on reactions of aryl Grignard reagents or lithiated heteroaromatics with protected 3,3′-dithiobisindoles is described. LÄS MER