Sökning: "bioreactor models"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden bioreactor models.

  1. 1. Interaction Analysis in Multivariable Control Systems : Applications to Bioreactors for Nitrogen Removal

    Författare :Björn Halvarsson; Bengt Carlsson; Elling Jacobsen; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; activated sludge process; biological nitrogen removal; bioreactor models; control structure design; cost-efficient operation; decentralized control; interaction measures; minimum variance control; multivariable control; wastewater treatment; Automatic control; Reglerteknik; Elektroteknik med inriktning mot reglerteknik; Electrical Engineering with specialization in Automatic Control;

    Sammanfattning : Many control systems of practical importance are multivariable. In such systems, each manipulated variable (input signal) may affect several controlled variables (output signals) causing interaction between the input/output loops. LÄS MER

  3. 2. Decellularized liver extracellular matrix as a 3D scaffold for bioengineering applications

    Författare :Vamakshi Khati; Aman Russom; Håkan Jönsson; Giulia Gaudenzi; Ana Teixeira; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; liver decellularization; decellularized liver matrix bioink; bioprinting; sacrificial scaffold; viscoelasticity; bioengineering; tumor modeling; stem cell differentiation; bioreactor; Biotechnology; Bioteknologi;

    Sammanfattning : The increasing global burden of end-stage liver disease has increased the need for liver transplantation, the definitive cure. However, there is a huge discrepancy between the number of available organ donors and the number of patients waiting for transplantation, resulting in the deaths of a significant number of patients on the waiting list as only 10% of the global need for transplantation is met. LÄS MER

  4. 3. Human embryonic stem cells for bone engineering applications

    Författare :Giuseppe Maria de Peppo; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human skeleton; bone; bone defects; bone regeneration; regenerative medicine; tissue engineering; biomaterials; scaffold; biocoral; titanium; osseointegration bioreactor; human stem cells; embryonic stem cells; mesenchymal stem cells; embryonic-derived progenitors; osteogenic differentiation; mineralization; immune response; in vitro; in vivo;

    Sammanfattning : The human skeleton represents the supporting structure of the organism and accounts for about 20 percent of the total body mass. Despite its intrinsic capacity to regenerate and self-repair, this ability is limited and repair therapies are needed in a large number of clinical cases. LÄS MER

  5. 4. Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials

    Författare :Elin Forsberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; uveal melanoma; patient-derived xenograft; immune-humanized mouse model; immunotherapy; adoptive T cell therapy; tumor-infiltrating lymphocytes; chimeric antigen receptor T CAR-T cells;

    Sammanfattning : Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic malignant melanoma will not be cured with available therapies today, and these patients require other treatment strategies. LÄS MER

  7. 5. Human liver in vitro models for evaluation of drug metabolism and disposition

    Författare :Malin Darnell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The administrated dose of a drug is adjusted to give a therapeutic effect in patients without causing side-effects or toxicity. Cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT) enzymes, uptake and efflux transporters and nuclear receptors regulating these enzymes, expressed in the liver and in other tissues, are all important players in drug metabolism, disposition and elimination. LÄS MER