Sökning: "biomarkers adducts"

Visar resultat 11 - 15 av 20 avhandlingar innehållade orden biomarkers adducts.

  1. 11. The use of protein biomarkers in ecotoxicology : Studies of oxidative and genotoxic stress in the blue mussel (Mytilus edulis)

    Författare :Andreas Prevodnik; Michael Tedengren; Tomas Bollner; Kari Lehtonen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Ecotoxicology; ekotoxikologi;

    Sammanfattning : Many environmental pollutants, heavy metals and polyaromatic hydrocarbons (PAHs) among them, are toxic by oxidative stress. Oxidative stress may be defined as a state in an organism when its inherent capacity to handle oxyradicals is surpassed, and it may result in peroxidation of lipids, and damage to proteins and DNA. LÄS MER

  3. 12. Protein adducts in plasma as biomarkers of exposure to and risk of organic acid anhydrides

    Författare :Seema Rosqvist; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GC-MS; IgG; IgE; exposure-response; serum albumin; biological monitoring; Hexahydrophthalic anhydride; methylhexahydrophthalic anhydride; OEL; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin;

    Sammanfattning : Organic acid anhydrides (OAAs) are important industrial chemicals but also potent inducers of airways diseases. Many exposed workers develop specific IgE and IgG antibodies. Hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA) are two particularly sensitising OAAs. LÄS MER

  4. 13. Biomarkers aiming at cancer risk estimation of polycyclic aromatic hydrocarbons

    Författare :Hans Helleberg; Kimmo Peltonen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical Biology; fysikalisk biologi;

    Sammanfattning : Polycyclic aromatic hydrocarbons (PAH), a family of compounds that are formed in incomplete combustion of organic matter, occur as general pollutants in air and food. Exposure to PAH is, according to preliminary estimates, associated with non-acceptable cancer risks showing the need for improved data to be used in risk estimation. LÄS MER

  5. 14. Quantitative analysis of DNA adducts formed by some epoxides of industrial importance

    Författare :Kamila Plná; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA adducts; 32P-postlabelling; cancer; genotoxicity; occupational; epoxides; allyl glycidyl ether; propylene oxide; epichlorohydrin;

    Sammanfattning : The work presented herein has focused on DNA adduct formation by three industrial epoxides, allyl glycidyl ether, propylene oxide and epichlorohydrin. Epoxides, owing to the strained oxirane ring are chemically reactive and can alkylate various sites in DNA. LÄS MER

  7. 15. Biomonitoring of epichlorohydrin and some related compounds

    Författare :Helena Hindsø Landin; Bo Jönsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biomarkers; DNA Adducts; Epichlorohydrin; Glycidol; Hemoglobin adducts.; Physical Biology; fysikalisk biologi;

    Sammanfattning : This thesis considers epichlorohydrin (ECH), an important industrial chemical, that has been shown to be a carcinogen in experimental animals. The aim of this work is to improve the scientific basis for risk estimation of ECH and to suggest a reliable biomonitoring method for exposure. LÄS MER