Sökning: "biomarker quantification"

Visar resultat 16 - 20 av 62 avhandlingar innehållade orden biomarker quantification.

  1. 16. Mass Spectrometry-Based Protein Biomarker Discovery in Pancreatic Cancer

    Författare :Qimin Zhou; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; proteomics; mass spectrometry; biomarkers; diagnosis; prognosis; prediction; BASP1; WT1; YAP1; AGP1;

    Sammanfattning : Background: Pancreatic cancer has the lowest survival rate among all the major cancer types. Although recent decades have seen advances in diagnostic imaging, surgical techniques, perioperative care and oncological treatment, this has not been translated into major improvements in clinical outcome. LÄS MER

  3. 17. Biophysical aspects of the skin barrier : towards increased non-invasive extraction and optimized biomarker sampling

    Författare :Maxim Morin; Johan Engblom; Sebastian Björklund; Nicole K Brogden; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The skin provides a link to the body’s health via its rich variety of high and low molecular weight biomarkers, reflecting both systemic diseases (e.g., cancer, diabetes) and local skin disorders (e.g. LÄS MER

  4. 18. Quality Control for high-throughput Quantitative Proteomics - Harnessing the potential of label-free LC-MS

    Författare :Marianne Sandin; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; mass spectrometry; quality control; data analysis; label-free; feature detection; alignment; biomarker discovery; separation techniques;

    Sammanfattning : Multiplex protein quantification, proteomics, is essential for uncovering new biomarkers and understanding biology. Liquid chromatography coupled to mass spectrometry (LC-MS) is the predominant technique for these measurements. LÄS MER

  5. 19. The immune microenvironment in mantle cell lymphoma : Targeted liquid and spatial proteomic analyses

    Författare :Lavanya Lokhande; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mantle cell lymphoma MCL ; proteomic analyses; spatial analysis; Biomarker discovery; immune microenviroment; serum proteomics;

    Sammanfattning : The complex interplay of the tumour and immune cells affects tumour growth, progression, and response to treatment. Restorationof effective immune response forms the basis of onco-immunology, which further enabled the development of immunotherapy. LÄS MER

  7. 20. Development and application of alternative methods for profiling proteins N-glycosylation

    Författare :Alessandro Quaranta; Leopold Ilag; Niclas Karlsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; N-glycosylation; Glycomics; Glycosylation Biomarkers; Intact Glycoproteins; Glycoform Quantification; Mass Spectrometry; Ion Mobility Spectrometry; MALDI-MS; Paper Spray Ionization; Microfluidics; Magnetic Beads; Immunoaffinity Purification; Nanobodies; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Glycosylation is a post-translational modification (PTM) that exerts profound structural and functional effects on the modified protein. Glycan synthesis and conjugation to proteins are regulated by a myriad of factors, both genetic and environmental, and are also influenced by external stressors. LÄS MER