Sökning: "biomarker discovery"

Visar resultat 21 - 25 av 95 avhandlingar innehållade orden biomarker discovery.

1. 21. Bead based protein profiling in blood

   Författare :Maja Neiman; Peter Nilsson; Jochen Schwenk; Anja Persson; Heng Zhu; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affinity proteomics; protein array; suspension bead array; antigen; antibody; biomarker discovery; serology; selectivity; sensitivity; serum; plasma;

   Sammanfattning : This thesis is about protein profiling in blood-derived samples using suspension bead ar- rays built with protein affinity reagents, and the evaluation of binding characteristics and potential disease relation of such profiles.A central aim of the presented work was to discover and verify disease associated protein profiles in blood-derived samples such as serum or plasma. LÄS MER

3. 22. Tailoring of Antibody Arrays - Technical Advances Towards Global Proteome Analysis

   Författare :Linn Petersson; Institutionen för immunteknologi; []
   Nyckelord :antibody arrays; recombinant antibodies; scFv; miniaturization of arrays; immobilization of scFv; global proteome analysis; biomarker discovery;

   Sammanfattning : Abstract The number of cancer and autoimmune disease diagnoses increases in our society, which place high demands on the health care system. Being able to tailor treatments for each individual patient is called "Personalized medicine", and could revolutionize the care in the future. LÄS MER

4. 23. Algorithms and Methods for Robust Processing and Analysis of Mass Spectrometry Data

   Författare :Jonatan Eriksson; Avdelningen för Biomedicinsk teknik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry; Algorithms; Signal Processing; Dynamic Programming; Biomarker discovery; High-dimensional data;

   Sammanfattning : Liquid chromatography-mass spectrometry (LC-MS) and mass spectrometry imaging (MSI) are two techniques that are routinely used to study proteins, peptides, and metabolites at a large scale. Thousands of biological compounds can be identified and quantified in a single experiment with LC-MS, but many studies fail to convert this data to a better understanding of disease biology. LÄS MER

5. 24. Tissue Microarrays for Analysis of Expression Patterns

   Författare :Cecilia Lindskog Bergström; Fredrik Pontén; Anna Asplund; Ari Ristimäki; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue microarrays; Antibody-based proteomics; Immunohistochemistry; Biomarker discovery; Diabetes; Lung cancer; Influenza virus; Evolution; Pathology; Patologi;

   Sammanfattning : Proteins are essential building blocks in every living cell, and since the complete human genome was sequenced in 2004, researchers have attempted to map the human proteome, which is the functional representation of the genome. One such initiative is the Human Protein Atlas programme (HPA), which generates monospecific antibodies towards all human proteins and uses these for high-throughput tissue profiling on tissue microarrays (TMAs). LÄS MER

7. 25. Development of Protein Microarray Chip Technology: An Outlook towards Proteomics and Diagnostics

   Författare :Anton Ressine; Avdelningen för Biomedicinsk teknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; materialteknik; Materiallära; Material technology; Teknik; Technological sciences; Naturvetenskap; Natural science; Diagnostik; Diagnostics; Medicin människa och djur ; Medicine human and vertebrates ; Biomedicinska vetenskaper; Biomedical sciences; water repellency; superhydrophobicity; proteolitic digestion; MALDI-TOF MS; bioassay; porous silicon; biomarker; diagnostics; protein microarrays; proteomics;

   Sammanfattning : One attractive method for monitoring biomolecular interactions in a highly parallel fashion is the use of microarrays. Microarrays can be applied for screening proteins which makes it an attractive tool in clinical diagnostics, drug discovery studies and basic protein research; even though many methodological challenges and ones relating to the quality control of microarrays still need to be solved. LÄS MER