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Visar resultat 1 - 5 av 95 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Biomarker Discovery in Cutaneous Malignant Melanoma : A Study Based on Tissue Microarrays and Immunohistochemistry

   Författare :Margrét Agnarsdóttir; Fredrik Ponten; Peter Naredi; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody-based proteomics; automated analysis; biomarker; immunohistochemistry; malignant melanoma; survival; tissue microarray; Tumour biology; Tumörbiologi; Pathology; Patologi; Molecular medicine; Molekylär medicin; Medical Science; Medicinsk vetenskap; Pathology; Patologi;

   Sammanfattning : The incidence of cutaneous malignant melanoma has increased dramatically in Caucasians the last few decades, an increase that is partly explained by altered sun exposure habits. For the individual patient, with a localized disease, the tumor thickness of the excised lesion is the most important prognostic factor. LÄS MER

3. 2. Advances for Biomarker Discovery in Neuroproteomics using Mass Spectrometry : From Method Development to Clinical Application

   Författare :Marcus O.D. Sjödin; Magnus Wetterhall; Jonas Bergquist; Dominic M. Desiderio; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry; Biomarker; Proteomics; Central Nervous System; Cerebrospinal Fluid; Traumatic Brain Injury; Cloud-Point Extraction; Neuroproteomics; Relative Quantification; Spinal Cord Stimulation; Neuropathic Pain; Analytical Chemistry; Analytisk kemi;

   Sammanfattning : Proteins offer a prominent group of compounds which may be ubiquitously affected in disease and used as biomarkers for early diagnosis, assessing treatment or drug development. Clinical proteomics aim to screen for protein biomarkers by a comprehensive analysis of all proteins expressed in a biological matrix during a certain pathology. LÄS MER

4. 3. Molecular Portraits of Cancer : Discovery of Biomarker Signatures using Affinity Proteomics

   Författare :Petter Skoog; Institutionen för immunteknologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Breast Cancer; Pancreatic cancer; antibody microarray; Immunosignature; Global Proteome Survey; Affinity proteomics; Biomarker;

   Sammanfattning : The use of antibodies as capture molecules in assays is a common practice. By either printing monoclonal single chain fragment variables (scFvs) on a solid support – recombinant antibody microarray – or attaching them to magnetic beads – Global Proteome Survey (GPS) – we can specifically capture and measure target proteins of interest. LÄS MER

5. 4. Biomarker Discovery in Autoimmune Diseases using Antibody Microarrays : Targeting Systemic Lupus Erythematosus

   Författare :Payam Delfani; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; affinity proteomics; antibody microarrays; biomarker discovery; SLE; data analysis;

   Sammanfattning : .... LÄS MER

7. 5. Molecular Characterisation and Prognostic Biomarker Discovery in Human Non-Small Cell Lung Cancer

   Författare :Karolina Edlund; Patrick Micke; Martin Schuler; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-small cell lung cancer; biomarker; prognosis; microarray; copy number aberration; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Non-small cell lung cancer (NSCLC) constitutes a clinically, histologically, and genetically heterogeneous disease entity that represents a major cause of cancer-related death. Early-stage patients, who undergo surgery with curative intent, experience high recurrence rates and the effect of adjuvant treatment is modest. LÄS MER