Sökning: "biologisk kemi"

Visar resultat 6 - 10 av 45 avhandlingar innehållade orden biologisk kemi.

  1. 6. Copper-transporting proteins and their interactions with platinum-based anticancer substances

    Författare :Maria Espling; Pernilla Wittung-Stafshede; Oleg Dmitriev; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cisplatin; Atox1; copper transport; anticancer drug; resistance; platinum; spectroscopy.; biologisk kemi; biological chemistry;

    Sammanfattning :   Cisplatin (CisPt) is an important drug that is used against various cancers, including testicular, ovarian, lung, head, and neck cancer. However, its effects are limited by cellular resistance. LÄS MER

  3. 7. Regulation of the multi-functional protein YscU in assembly of the Yersinia type III secretion injectisome

    Författare :Ho Ngoc Hoang Oanh; Magnus Wolf-Watz; Anna Linusson Jonsson; Maria Sunnerhagen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Type III secretion system T3SS ; injectisome; Yersinia pseudotuberculosis; inhibitors; Yops; YscU; YscP; YscI; disorder-to-order transition; nuclear magnetic resonance NMR ; circular dichroism CD ; isothermal titration calorimetry ITC ; biologisk kemi; biological chemistry;

    Sammanfattning : Yersinia pseudotuberculosis is a Gram-negative zoonotic pathogenic bacterium causing gastroenteritis in human and animals. It shares a conserved virulence plasmid encoding for a needle-like secretion machinery, or type III secretion system, which can be found in other pathogenic Gram-negative bacteria. LÄS MER

  4. 8. Small Molecules as Tools in Biological Chemistry : Effects of Synthetic and Natural Products on the Type III Secretion System

    Författare :Caroline E. Zetterström; Mikael Elofsson; Samuel I. Miller; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Type III secretion; salicylidene acylhydrazide; virulence-blocker; virulence; inhibitor; target identification; neohopeaphenol A; Yersinia pseudotuberculosis; Pseudomonas aeruginosa; Escherichia coli; biologisk kemi; biological chemistry;

    Sammanfattning : The increasing use of antibiotics has led to a huge problem for society, as some bacteria have developed resistance towards many of the antibiotics currently available. To help find solutions to this problem we studied small molecules that inhibit bacterial virulence, the ability to cause disease. LÄS MER

  5. 9. Multivariate Analysis of 2D-NMR Spectroscopy : Applications in wood science and metabolomics

    Författare :Tommy Öman; Mattias Hedenström; Bjart Frode Lutnaes; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 2D NMR; HSQC; cellulose; ligning; STOCSY; HSQC-STOCSY; crystallinity; biologisk kemi; biological chemistry;

    Sammanfattning : Wood is our most important renewable resource. We need better quality and quantity both according to the wood itself and the processes that are using wood as a raw material. Hence, the understanding of the chemical composition of the wood is of high importance. LÄS MER

  7. 10. Water-swelling tablets based on hydrophobically modified poly(acrylic acid) - Effects of amphiphiles on swelling and drug release

    Författare :Patrik Knöös; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drug deliver; Controlled release; Hydrophobically modified polymers; Surfactant-polymer interactions; Poorly soluble drug;

    Sammanfattning : An important issue within the pharmaceutical world today is the increasing number of poorly soluble drugs. These often show a low bioavailability and a susceptibility to varying conditions in the intestine. LÄS MER