Sökning: "biologically active compounds"

Visar resultat 1 - 5 av 40 avhandlingar innehållade orden biologically active compounds.

  1. 1. Primary Recovery of Biologically Active Compounds Using Macroporous Monolithic Hydrogels

    Detta är en avhandling från Biotechnology, Lund University

    Författare :Amro Hanora; [2005]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Downstream processing; macroporous; Biologically active compounds; Biotechnology; Läkemedelsteknik och relaterad teknik; Pharmaceutical and related technologies; Polymerteknik; biopolymers; Biokemisk teknik; Polymer technology; Makromolekylär kemi; Biochemical technology; Affinity chromatography; Ion exchange chromatography; Expanded bed adsorption chromatography.; Macromolecular chemistry; High through put screening; lactica acids; Endotoxin; Plasmid DNA; Cryogel columns; Bioteknik;

    Sammanfattning : The completion of sequencing of human and other mammalian genomes opens a new era for drug development. New approaches have been proposed for tackling diseases such as development of small molecule therapies based on understanding of human genome and proteome, new proteinous based therapies, where the therapeutic protein can inhibit or modify a certain metabolic pathway or DNA-based therapies delivering a gene into the cell (e. LÄS MER

  2. 2. Novel biologically active compounds by semisynthesis with fungal metabolites

    Detta är en avhandling från Department of Bioorganic Chemistry, Lund University

    Författare :Johan Eriksson Bajtner; [2004]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; bioactive compounds.; isovelleral; podoscyphic acid; Natural products; semisynthesis;

    Sammanfattning : Natural products have been shown to be an important source of novel compounds for the development of new drugs and pesticides. However, many biologically active natural products contain reactive functionalities that make them toxic. LÄS MER

  3. 3. Biologically Interesting Compounds from Natural Sources

    Detta är en avhandling från Organic Chemistry, Lund University

    Författare :Veronica de la Parra; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytotoxicity; Natural products; terpenoids; vasorelaxant activity; allylmercaptane; diabetes mellitus type II; Organisk kemi; Organic chemistry; Cacalia decomposita; GPR40 receptor; TRP channel;

    Sammanfattning : Natural products have traditionally played a major role in the drug discovery process. Besides constituting extremely popular drugs in the market, and an ever-increasing source of interesting and novel chemical structures, they have also aided the characterization of many a pharmacological target. LÄS MER

  4. 4. Synthesis Towards Biologically Active Natural Products

    Detta är en avhandling från Department of Chemistry, Lund University

    Författare :Rikard Larsson; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transtaganolide; basiliolide; natural product; total synthesis; biomimetic; Thapsia; Diels-Alder; Ireland-Claisen; Pictet-Spengler; tetrahydroisoquinoline; indole;

    Sammanfattning : In 2005 two research groups independently reported the isolation of a series of structurally intriguing C-19 terpenolides from the plants Thapsia transtagana and Thapsia garganica. The compounds were shown to be potent inhibitors of the sarco/endoplasmic reticulum Ca2+-ATPases. LÄS MER

  5. 5. Mass Spectrometry of Biologically Active Small Molecules Focusing on polyphenols, alkaloids and amino acids

    Detta är en avhandling från Stockholm : Department of Analytic Chemistry, Stockholm University

    Författare :Zdeněk Spáčil; Stockholms universitet.; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LC-MS; LDI; Mass spectrometry; HPLC; UHPLC; polyphenols; phenolic acids; BMAA; NATURAL SCIENCES Chemistry Analytical chemistry Separation methods; NATURVETENSKAP Kemi Analytisk kemi Separationsmetoder; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : The foci of this dissertation are on advanced liquid chromatography (LC) separation and mass spectrometry (MS) techniques for the analysis of small bioactive molecules. In addition to discussing general aspects of such techniques the results from analyses of polyphenols (PPs), alkaloids and amino acids published in five appended studies are presented and discussed. LÄS MER