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Visar resultat 1 - 5 av 635 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Improved Neuropeptide Identification : Bioinformatics and Mass Spectrometry

   Författare :Maria Fälth Savitski; Per Andrén; David Fenyö; Per Svenningsson; Ronald Beavis; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; neuropepides; database; peptide identification; peptide fragmentation; mass spectrometry; tandem mass spectromerty; Bioinformatics; Bioinformatik;

   Sammanfattning : Bioinformatic methods were developed for improved identification of endogenous peptides using mass spectrometry. As a framework for these methods, a database for endogenous peptides, SwePep, was created. It was designed for storing information about endogenous peptides including tandem mass spectra. LÄS MER

3. 2. A Study in RNA Bioinformatics : Identification, Prediction and Analysis

   Författare :Eva Freyhult; David Ardell; Robert Giegerich; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA; bioinformatics; secondary structure; structure prediction; dynamic programming; energy landscape; homology search; sequence logo; tRNA; Bioinformatics; Bioinformatik;

   Sammanfattning : Research in the last few decades has revealed the great capacity of the RNA molecule. RNA, which previously was assumed to play a main role only as an intermediate in the translation of genes to proteins, is today known to play many important roles in the cell in addition to that as a messenger RNA and transfer RNA, including the ability to catalyze reactions and gene regulations at various levels. LÄS MER

4. 3. A Bioinformatics Study of Human Transcriptional Regulation

   Författare :Adam Ameur; Jan Komorowski; Claes Wadelius; Philipp Bucher; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; microarray; ChIP-chip; ChIP-seq; transcription factor; histone modification; motif search; Bioinformatics; Bioinformatik;

   Sammanfattning : Regulation of transcription is a central mechanism in all living cells that now can be investigated with high-throughput technologies. Data produced from such experiments give new insights to how transcription factors (TFs) coordinate the gene transcription and thereby regulate the amounts of proteins produced. LÄS MER

5. 4. Grid and High-Performance Computing for Applied Bioinformatics

   Författare :Jorge Andrade; Jacob Odeberg; Luciano Milanesi; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Grid computing; bioinformatics; genomics; proteomics; Bioinformatics; Bioinformatik;

   Sammanfattning : The beginning of the twenty-first century has been characterized by an explosion of biological information. The avalanche of data grows daily and arises as a consequence of advances in the fields of molecular biology and genomics and proteomics. LÄS MER

7. 5. eScience Approaches to Model Selection and Assessment : Applications in Bioinformatics

   Författare :Martin Eklund; Jarl Wikberg; Ron Wehrens; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; high-throughout biology; eScience; model selection; model assessment; Bioinformatics; Bioinformatik;

   Sammanfattning : High-throughput experimental methods, such as DNA and protein microarrays, have become ubiquitous and indispensable tools in biology and biomedicine, and the number of high-throughput technologies is constantly increasing. They provide the power to measure thousands of properties of a biological system in a single experiment and have the potential to revolutionize our understanding of biology and medicine. LÄS MER