Sökning: "biochemistry"

Visar resultat 21 - 25 av 1833 avhandlingar innehållade ordet biochemistry.

  1. 21. Structural and biochemical studies of phage P2 DNA-binding proteins and human tetraspanins

    Författare :Karin Skaar; Martin Högbom; Simon Newstead; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

    Sammanfattning : Biochemical studies of proteins are crucial for a more detailed view of the world around us. The focus of biochemical studies can vary, from a complex mammalian system to a more simple viral entity, but the same methods and principles apply. In biochemistry one rely on both in vitro and in vivo analyses to understand biological processes. LÄS MER

  3. 22. The birth of the hydrogenase : Studying the mechanism of [FeFe] hydrogenase maturation

    Författare :Brigitta Németh; Gustav Berggren; Ann Magnuson; Mohamed Atta; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HydF; HydA; [FeFe] hydrogenase maturation; semi-synthetic enzymes; Biokemi; Biochemistry;

    Sammanfattning : The [FeFe] hydrogenases are ancient metalloenzymes that catalyse the reversible interconversion between protons, electrons and molecular hydrogen. Despite the large structural variability within the [FeFe] hydrogenase family, the active site, the so called “H-cluster” is present in every representative. LÄS MER

  4. 23. Discovery and evaluation of direct acting antivirals against hepatitis C virus

    Författare :Eldar Abdurakhmanov; Helena Danielson; David Frick; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Direct acting antivirals; Hepatitis C; NS3-4A protease; NS5B polymerase; structure-based drug discovery; fragment-based drug discovery; surface plasmon resonance; Biokemi; Biochemistry;

    Sammanfattning : Until recently, the standard therapy for hepatitis C treatment has been interferon and ribavirin. Such treatment has only 50% efficacy and is not well tolerated. The emergence of new drugs has increased the treatment efficacy to 90%. LÄS MER

  5. 24. Structural studies on the integral membrane protein, ubiquinol oxidase from Escherichia coli

    Författare :Jeff Abramson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; crystal structure; ubiquinol oxidase; membrane protein; oxidases; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Heme-copper oxidases are redox-driven proton pumps that couple the reduction of molecular oxygen to water with the vectorial translocation of protons across the membrane. The proton gradient generated by heme-copper oxidases and the other members of the aerobic respiratory chain is ultimately used to drive the synthesis of ATP. LÄS MER

  7. 25. Folding and interaction studies of subunits in protein complexes

    Författare :Ximena Aguilar; Stefan Björklund; Alexis Verger; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Macromolecular crowding; cpn10; Mediator; Med25; Dreb2a; VP16; conformational changes; NMR; ITC.; biokemi; Biochemistry; molekylärbiologi; Molecular Biology;

    Sammanfattning : Proteins function as worker molecules in the cell and their natural environment is crowded. How they fold in a cell-like environment and how they recognize their interacting partners in such conditions, are questions that underlie the work of this thesis. LÄS MER