Sökning: "biochemical resistance"

Visar resultat 1 - 5 av 83 avhandlingar innehållade orden biochemical resistance.

  1. 1. Structural and Biochemical Studies of Antibiotic Resistance and Ribosomal Frameshifting

    Författare :Yang Chen; Maria Selmer; Dominique Fourmy; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein synthesis; elongation; elongation factor G; fusidic acid; antibiotic resistance; aminoglycoside adenyltransferase; ribosomal frameshifting; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : Protein synthesis, translation, performed by the ribosome, is a fundamental process of life and one of the main targets of antibacterial drugs. This thesis provides structural and biochemical understanding of three aspects of bacterial translation.Elongation factor G (EF-G) is the target for the antibiotic fusidic acid (FA). LÄS MER

  3. 2. Microbotryum violaceum on Silene dioica : understanding traits that influence plant-pathogen interactions

    Författare :Åsa Granberg; Barbara E. Giles; Ulla Carlsson-Granér; Arjen Biere; Umeå universitet; []
    Nyckelord :plant-pathogen interaction; biochemical resistance; breeding system; automixis; race specific resistance; extinction-colonisation dynamics; Silene dioica; Microbotryum violaceum;

    Sammanfattning : The dynamics of a plant-pathogen interaction vary both within and among species. Both spatial structuring and specific genetic and life-history characteristics will affect the interaction and the outcome of a potential co-evolution between the two organisms. LÄS MER

  4. 3. Insulin resistance and cardiovascular function - Observational, translational and interventional studies

    Författare :Helena Utkovic Westergren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin resistance; microvascular function; peripheral vascular function; coronary flow reserve; prognosis; myocardial perfusion scintigram; animal model;

    Sammanfattning : Background: Microvascular disease is now recognized as an important driver for cardiovascular mortality and morbidity. Diabetic patients are known to suffer from this condition, leading to e.g. coronary ischemia as well as kidney dysfunction. LÄS MER

  5. 4. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : Targeting Different Genotypes and Drug-Resistant Variants

    Författare :Anna Karin Belfrage; Anja Sandström; Ulf Ellervik; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitors; structure-activity relationship; 2 1H -pyrazinone; quinazoline; resistance; Pd catalysis; Medicinal Chemistry; Läkemedelskemi; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are available for chronic HCV infections. LÄS MER

  7. 5. Generation and exploitation of proton motive force: Biochemical and structural analysis of three bacterial integral membrane proteins

    Författare :Pontus Emanuel Gourdon; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; AcrB; structure; proteorhodopsin; multi-drug resistance; transhydrogenase; membrane proteins; proton motive force;

    Sammanfattning : Proton motive force, a necessity for all living cells, is generated and exploited by asignificant number of membrane-bound enzymes and transporters. The focus of thisthesis was to understand the physiological relevance, structure and mechanism of threesuch bacterial enzymes: proteorhodopsin; transhydrogenase; and AcrB. LÄS MER