Sökning: "bidirectional promoter"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden bidirectional promoter.

  1. 1. Evolution of protein and non-coding RNA genes studied with comparative genomics

    Författare :Marcela Davila Lopez; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Bioinformatics; evolution; non-coding RNA; gene prediction; gene order; bidirectional promoter; homologue prediction; secondary structure; RNAse P; RNase MRP;

    Sammanfattning : The identification of protein and non-coding RNA (ncRNA) genes is one important step in the analysis of a genome. This thesis focuses on the identification and analysis of proteins and ncRNAs homologues by exploiting a variety of computational methods in order to reach conclusions as to their structure, function, evolution and regulation. LÄS MER

  2. 2. Novel Synthetic Biology Tools for Metabolic Engineering of Saccharomyces cerevisiae

    Författare :Siavash Partow; Chalmers University of Technology; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yeast promoter; MVA pathway; Metabolic engineering; Multi-copy plasmid.; Synthetic biology; S. cerevisiae; MEP pathway;

    Sammanfattning : The most well characterized eukaryote model organism Saccharomyces cerevisiae is not only preferred as a microbial cell factory for synthesis of industrial products, e.g. bioethanol, but this eukaryote host system is also defined as a robust scaffold for commercial production of diverse chemicals e.g. LÄS MER

  3. 3. Type IV collagen : regulation of COL4A1 and COL4A2 genes and gene therapy of Alport syndrome

    Författare :Pirkko Kortteinen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; adenovirus; Alport syndrome; basement membrane; bidirectional promoter; collagen; gene regulation; gene therapy; promoter analysis; kidney gene transfer; organ perfusion; type IV collagen;

    Sammanfattning : Type IV collagen is an important structural protein in basement membranes, which am thin sheet-like structures located between organized tissues and the connective tissue. Type IV collagen is composed of six genetically different [alpha] chains. LÄS MER

  4. 4. EWSR1 and FUS fusion genes in tumorigenesis

    Författare :Emely Möller; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The present thesis concerns the involvement of EWSR1 and FUS fusion genes, and the chimeric proteins they encode, in tumorigenesis. In Article I, the EWSR1 promoter, which regulates the expression of EWSR1 fusion genes, was characterized and regions that were crucial for promoter activity could be identified. LÄS MER

  5. 5. Molecular diagnostics of infectious diseases

    Författare :Malin Nygren; KTH; []
    Nyckelord :;

    Sammanfattning : In DNA-based diagnostics, the polymerase chain reaction(PCR) is the most widely used DNA amplification method. Toenable both sensitive and specific detection of agents causinginfectious diseases, the PCR needs to becombined with methodsto prepare the clinical sample containing the genetic materialof the pathogen. LÄS MER