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1. 1. Studies on host-related pathogenesis of herpes simplex type-1 encephalitis in rat

   Författare :Biborka Bereczky-Veress; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : In order to explore the molecular mechanisms of Herpes simplex encephalitis (HSE), a severe infection of the central nervous system (CNS) caused by Herpes simplex type 1 virus (HSV-1); a rat model resembling the human condition was characterized in the DA (Dark Agouti) strain. After injection into the whiskers’ area HSV-1 entered the CNS at the level of the brain stem via the trigeminal ganglion, subsequently spreading to the thalamus, cortex and olfactory bulb, leading to death at five days post infection (dpi). LÄS MER