Sökning: "beta-lactamase"

Visar resultat 11 - 15 av 30 avhandlingar innehållade ordet beta-lactamase.

  1. 11. Novel diagnostic methods for rapid characterization of extended-spectrum beta-lactamase- and carbapenemase-producing Enterobacteriaceae

    Författare :Muhammad Humaun Kabir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Klebsiella pneumoniae and Escherichia coli are two of the most clinically important pathogens of the family Enterobacteriaceae. Both can cause severe infections includ-ing urinary tract infections (UTI), bloodstream infections (BSI) and pneumonia. Both are also involved in dissemination of antibiotic resistance. LÄS MER

  3. 12. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development

    Författare :Lisa Allander; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Arnfinn Sundsfjord; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria; antibiotic combination therapy; antibiotic resistance; beta-lactams; beta-lactamase inhibitors; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. LÄS MER

  4. 13. Go with your gut : The human intestinal microbiota, international travel, Campylobacter and ESBL-producing Enterobacteriaceae

    Författare :Christian Kampmann; Hilpi Rautelin; Johan Dicksved; Lars Engstrand; Johan Tham; Johan Ursing; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; travel; travellers´diarrhea; microbiota; Campylobacter; Campylobacter jejuni; ST353CC; colonization resistance; enteritis; infection; Enterobacteriaceae; Christensenellaceae; Lachnospiraceae; whole genome sequence; vegetarian; bacterial resistance; ESBL; Extended spectrum beta-lactamase; probiotics; intestinal decolonization; eradication treatment; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Up to 100 million people travel annually from industrialized countries to resource-limited ones. Each traveller contains an internal ecosystem composed of tens of trillions of microbes, known as the intestinal microbiota, which has a large effect on health. LÄS MER

  5. 14. Enterobacteriaceae Producing Extended-Spectrum Beta-Lactamases : Aspects of Detection, Epidemiology and Control

    Författare :Birgitta Lytsy; Åsa Melhus; Dan Andersson; Håkan Hanberger; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Extended-spectrum beta-lactamase; ESBL; pulse-field gel elctrophoresis; typing methods; infection control; typningsmetoder; vårdhygien; Bacteriology; Bakteriologi; Clinical Bacteriology; Klinisk bakteriologi;

    Sammanfattning : Enterobacteriaceae belong to the normal enteric flora in humans and may cause infections. Escherichia coli is the leading urinary tract pathogen with septicaemic potential, whereas Klebsiella pneumoniae causes opportunistic infections and often outbreaks in hospital settings. LÄS MER

  7. 15. Beta-lactam and metronidazole resistance in the Bacteroides fragilis group

    Författare :Hong Fang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bacteroides fragilis group; beta-lactam; metronidazole; resistance; beta-lactamase; penicillinbinding proteins PBPs ; outer membrane proteins OMPs ;

    Sammanfattning : The Bacteroides fragilis group organisms are anaerobic gram-negative bacilli. Ten species are currently included in this group. Members of the B. fragilis group are the major constituents of the normal colonic microflora and the most commonly encountered anaerobic bacteria in clinical specimens. LÄS MER