Sökning: "beta relaxation"
Visar resultat 1 - 5 av 19 avhandlingar innehållade orden beta relaxation.
1. Water and protein solutions studied by field-dependent magnetic relaxation
Sammanfattning : In the work presented, nuclear magnetic resonance (NMR) relaxation is used to study wide range of systems. The thesis concerns solvent interactions studied with relaxation techniques that involve measurements at many fields, which allows the separation of individual relaxation mechanisms. LÄS MER
2. Magnetic relaxation studies of self-associating and membrane proteins
Sammanfattning : Magnetic relaxation dispersion measurements have been performed on aqueous protein solutions to study the dynamics of waters in the proton transport channel of bacteriorhodopsin and the self-association of the proteins BPTI, lysozyme and beta-lactoglobulin. The measurements have focused on the bulk relaxation rates, R1 and R2, of three water nuclei 1H, 2H and 17O that are coupled to the protein environments by exchange and therefore report on properties such as the protein tumbling and dynamics of internal waters. LÄS MER
3. Cardiovascular beta-adrenergic signaling : Maturation and programming effects of hypoxia in a chicken model
Sammanfattning : Despite the importance of β-adrenergic receptors (βARs) in cardiovascular disease, not much is known about how prenatal hypoxia effects βAR signaling in the postnatal animal. Thus, the aim of this thesis was to characterize the pre- and postnatal maturation of the cardiovascular βARs and the effects of chronic prenatal hypoxia on βAR signaling in the embryo and adult animal using the chicken as experimental model. LÄS MER
4. NMR studies of the amyloid beta-peptide
Sammanfattning : The Amyloid beta peptide (Ab) is related to Alzheimer’s disease and is suggested to be the molecular pathogenic species of the disease, probably through the neurotoxic effect of Ab oligomers. Here the results from biophysical studies of Ab and fragments thereof, are presented. LÄS MER
5. NMR STUDIES ON STRUCTURE AND DYNAMICS OF TWO-DOMAIN PROTEINS
Sammanfattning : The general objective of the present thesis work was to examine 3-dimensional structure as well as the motional properties of two different types of two-domain proteins by solution-state NMR. One of the major tasks of this thesis work was to investigate the domain orientation of these molecules by employing residual dipolar couplings (RDC) which can be used as orientational restraints for increasing the accuracy of protein structures determined by NMR. LÄS MER