Sökning: "beta cells"

Visar resultat 21 - 25 av 632 avhandlingar innehållade orden beta cells.

  1. 21. Cellular responses to amyloid-beta protofibrils : Focus on astrocytes, extracellular vesicles and antibody treatment

    Författare :Elisabeth Nikitidou; Anna Erlandsson; Martin Ingelsson; Gunnar K. Gouras; Uppsala universitet; []
    Nyckelord :Alzheimer’s disease; Amyloid-beta; Protofibrils; Astrocytes; Extracellular vesicles; Antibody; Neurons; Degradation; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Knowledge about the cellular mechanisms behind the initiation and propagation of Alzheimer’s disease (AD) is limited. Decades of research have focused on neuronal abnormalities in AD, but recently more attention has been given to the glial cells. LÄS MER

  3. 22. Effects of Antioxidants and Pro-oxidants on Oxidative Stress and DNA Damage using the Comet Assay : Studies on Blood Cells from Type 2 Diabetes Subjects and Mouse Lymphoma Cells

    Författare :Rikard Åsgård; Björn Hellman; Leif Busk; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolic syndrome; fruit and vegetable intake; plasma antioxidants; beta-carotene; alpha-tocopherol; inflammation; oxidative DNA damage; lipid peroxidation; mouse lymphoma assay; ROS; nucleotide pool; viability; DNA dye; Toxicology; Toxikologi;

    Sammanfattning : Diet and oral supplements comprise two distinct sources of antioxidants known to prevent oxidative stress. Beneficial effects from antioxidants have been seen for patients at risk for type 2 diabetes.The aim of this thesis was to evaluate the positive effects of antioxidants against oxidative stress and DNA damage in type 2 diabetes subjects. LÄS MER

  4. 23. Maf transcription factors in beta cell function

    Författare :Elvira Ganic; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Beta cell; MafA; type 2 diabetes; insulin secretion; transcription; monoamine oxidase; MaoA; MaoB; nicotinic receptor subunits; nAChRs;

    Sammanfattning : Diabetes mellitus is metabolic disorder caused by a defect or lack of beta cell-produced insulin that controls blood glucose homeostasis. In addition to glucose, insulin secretion is regulated by the autonomic nervous system (ANS); the neurotransmitter acetylcholine as well as monoamines, such as dopamine, serotonin, melatonin and norepinephrine. LÄS MER

  5. 24. Exocytosis in insulin secreting cells - role of SNARE-proteins

    Författare :Jenny Vikman; Diabetes - öcellsexocytos; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium channel; cAMP; syntaxin 1; SNAP-25; SNARE; exocytosis; Insulin secretion; pancreatic beta-cells;

    Sammanfattning : Type 2 diabetes is marked by deterioration in pancreatic β-cell function. SNARE-proteins are crucial for the fusion of insulin granules with the plasma membrane, a prerequisite for insulin secretion. LÄS MER

  7. 25. Palmitate-induced Apoptosis in Insulin-producing β-cells

    Författare :Kristofer Thörn; Peter Bergsten; Claes Wollheim; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ER stress; apoptosis; palmitate; sphingosine-1-phosphate; ceramide; beta-cell; fatty acid; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Type 2 diabetes is a disease characterized by the inability of pancreatic β-cells to secrete sufficient amounts of insulin to maintain normoglycemia. Increased levels of saturated fatty acids such as palmitate are believed to contribute to β-cell failure and the development of the disease. LÄS MER