Sökning: "beta amyloid protein"

Visar resultat 1 - 5 av 118 avhandlingar innehållade orden beta amyloid protein.

  1. 1. Amyloid Beta – Biotherapy Target and Biotechnological Tool

    Författare :Sebastian W. Meister; Stefan Ståhl; John Löfblom; Maarten Merkx; KTH; []
    Nyckelord :Alzheimer’s disease; amyloid beta; blood-brain barrier; green-fluorescent protein; intracellular assays; proteases; protease substrate specificity; protein aggregation; protein engineering.; Bioteknologi; Biotechnology;

    Sammanfattning : Alzheimer’s disease is a progressive neurodegenerative disease characterized primarily by memory impairment and cognitive decline. As of 2020, an estimated 50 million people suffer from Alzheimer’s disease or related dementia and no disease-modifying treatment options are yet approved for clinical practice. LÄS MER

  3. 2. The amyloid : structure, properties and application

    Författare :Mantas Malisauskas; Ludmilla Morozova-Roche; Fabrizio Chiti; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; oligomers; AFM; cytotoxicity; biotemplating; lysozyme; Biochemistry; Biokemi;

    Sammanfattning : Protein aggregation, leading to the formation and depositions of amyloids, is a cause for a number of diseases such as Alzheimer’s and Creutzfeld-Jacob’s disease, systemic amyloidoses, type II diabetes and others . More than 20 proteins are associated with protein misfolding diseases and even a larger number of proteins can self-assemble into amyloid in vitro. LÄS MER

  4. 3. Synthesis of Ring-fused Peptidomimetics : Interacting with Amyloid Fibrils

    Författare :Dan E. Adolfsson; Fredrik Almqvist; Anna Linusson; Morten Grötli; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; synthesis; peptidomimetics; thiazoline fused 2-pyridones; Alzheimer s disease; Parkinson s disease; Amyloid; Amyloid-beta; alfa-Synuclein; method development; organisk kemi; Organic Chemistry;

    Sammanfattning : Parkinson's and Alzheimer's disease are the two most common neurological disorders in humans. Both conditions involve progressive death of neurons in the central nervous system, decline in bodily functions and eventually (and invariably), death. So far, no cure exists and the available treatments can only ease symptoms. LÄS MER

  5. 4. Unravelling protein stability and aggregation

    Författare :Tanja Weiffert; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein stability; protein aggregation; amyloid beta peptide; protein stabilization; split GFP; monellin; secretagogin; ; aggregation kinetics; toxicity; aggregation mechanism; coaggregation;

    Sammanfattning : Proteins are complex macromolecules that are fundamental to all living species. The stability of proteins are governed by non-covalent forces within the protein and between the protein and its surrounding environment. LÄS MER

  7. 5. Proislet Amyloid Polypeptide (proIAPP) : Impaired Processing is an Important Factor in Early Amyloidogenesis in Type 2 Diabetes

    Författare :Johan F. Paulsson; Gunilla Westermark; Christer Betsholtz; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biosynthesis amyloid; Genetics amyloid; Metabolism amyloid; Islets of Langerhans; Proprotein convertases; Posttranslation protein processing; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : Amyloid is defined as extracellular protein aggregates with a characteristic fibrillar ultra-structure, Congo red affinity and a unique x-ray diffraction pattern. At present, 25 different human amyloid fibril proteins have been identified, and amyloid aggregation is associated with pathological manifestations such as Alzheimer’s disease, spongiform encephalopathy and type 2 diabetes. LÄS MER