Sökning: "behavioral senescence"

Hittade 5 avhandlingar innehållade orden behavioral senescence.

  1. 1. The role of insulin signaling during development, reproductive diapause and aging in Drosophila Melanogaster

    Författare :Sifang Liao; Dick Nässel; Heinrich Dircksen; Mark Brown; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; insulin-like peptides; reproductive diapause; behavioral senescence; neuromodulator; lifespan; funktionell zoomorfologi; Functional Zoomorphology;

    Sammanfattning : The insulin/insulin-like growth factor signaling pathway exists from invertebrates to vertebrates and it can regulate various biological processes, including development, metabolism, stress resistance and lifespan. In Drosophila, eight insulin-like peptides (DILP1-8) have been found. LÄS MER

  3. 2. Old-age muscle atrophy : cellular mechanisms and behavioral consequenses

    Författare :Mikael Altun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : With advancing age, humans and rodents alike lose about one third of the skeletal muscle mass. A process referred to as old-age muscle atrophy or sarcopenia. LÄS MER

  4. 3. Spinal motoneurones and the bulbospinal serotonininergic system in aged rats with behavioral deficits

    Författare :Hans Johnson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :aging; behavior; immunohistochemistry; in situ hybridisation; motoneuron; CGRP; axotorny; GAP-43; neurotrophin receptors; degeneration; axon dystrophy; 5HT TRH; SP; 5HLkA; AADC; serotonintransporter protein; fluoxetine; L-5-HTP;

    Sammanfattning : The expression of neuropeptides, growth-related proteins and neurotrophin receptors were studied in motoneurons of young adult rats and in aged rats with symptoms of neuromuscular incapacities. Also studied were aging-related changes in the descending serotoninergic (5HT) bulbospinal system which constitutes a major afferent pathway to spinal motoneurons. LÄS MER

  5. 4. Changes in sensory systems during aging : an experimental study in the rat

    Författare :Esbjörn Bergman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :aging; behavior; primary sensory neuron; dorsal root ganglion; mystacial pad; sensory nerve ending; axon dystrophy; neuropeptides; B4; RT97; CTB; neurotrophins; trk; p75NTR; GFR[alpha]; RET; protein; mRNA;

    Sammanfattning : Aging is associated with sensorimotor disturbances, including increased proprioceptive thresholds. The present study aimed to clarify the occurrence of structural and biochemical alterations in sensory systems of behaviorally characterized aged rats. LÄS MER

  7. 5. On age related changes in axons and glia of the central nervous system

    Författare :Susanna Kullberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aging; synaptic input; spinal cord; hippocampus; amino acid neurotransmitters; astrocyte; microglia; oligodendroglia; C bouton; cholinergic; monoaminergic; cytokine;

    Sammanfattning : A growing body of evidence shows that phenotypic changes including axon aberrations, rather than loss of neurons, account for behavioral impairments during aging. The present thesis was undertaken to investigate the occurrence of axon aberrations in relation to transmitter identity, glial reaction and sensorimotor disturbances. LÄS MER