Sökning: "basolateral"

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet basolateral.

  1. 1. Isolation of caveolae using affinity two-phase partitioning

    Författare :Parisa Abedinpour; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; metabolism; Biokemi; Metabolism; Biochemistry; basolateral; apical; immunoaffinity; wheat germ agglutinin; caveolin; caveolae caveolae enriched fraction; plasma membranes; rat lung; rat liver; Affinity Partitioning; two-phase partitioning;

    Sammanfattning : The intention of this work was to establish alternative purification methods to obtain highly purified caveolae from various tissues. In order to isolate caveolae, sufficiently pure plasma membranes are needed. LÄS MER

  3. 2. Overlapping Neural Substrates of Alcohol- and Anxiety-Related Behavior in the Rat

    Författare :Riccardo Barchiesi; Estelle Barbier; Markus Heilig; Annika Thorsell; Andrew Holmes; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alcohol use disorder; Anxiety disorder; Behavior; Rat; Prelimbic cortex; Amygdala; Basolateral amygdala; Stress; Epigenetics; Syt1; Prdm2; Avp; Conditioned fear; Social defeat stress; Witness stress; Susceptibility; Resilience;

    Sammanfattning : Alcohol use is a leading cause of death and disease worldwide. A large part of this disease burden is associated with alcohol use disorder (AUD), a diagnostic category characterized by excessive use in spite of negative consequences ("compulsive use"), a loss of control over intake, and choice of alcohol over natural rewards. LÄS MER

  4. 3. Hippocampal circuit dynamics in learning and value processing of sensory cues : A study into the function of hippocampal microcircuits involving OLMα2 cells

    Författare :Samer Siwani; Klas Kullander; Michael Hasselmo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The anatomical signatures of the mnemonic/emotional processes share many brain structures, one of which seems to constitute a bridge, the hippocampus. It functions as a structure that consolidates engrams. It is connected to the prefrontal cortex, nucleus accumbens and amygdala, structures that provide emotional salience. LÄS MER

  5. 4. Stereoselective Transport of Drugs Across the Blood-Brain Barrier (BBB) In Vivo and In Vitro : Pharmacokinetic and Pharmacodynamic Studies of the (S)- and (R)-Enantiomers of Different 5-HT1A Receptor Agonists and Antagonists

    Författare :Hongmei Yan; Lennart Paalzow; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; pindolol; propranolol; 2- di-n-propylamino tetralin; racemate; enantiomer; drug distribution; brain; rat; blood-brain barrier; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

    Sammanfattning : Delivery of drugs to the brain requires passage across the blood-brain barrier (BBB). Both for drugs already on the market and for new drugs under development, it is important to know to what extent a drug enters the CNS. Many drugs used clinically are racemic mixtures, i.e. LÄS MER

  7. 5. Pathogenesis of an emerging pathogen : Crimean-Congo hemorrhagic fever virus

    Författare :Anne-Marie Connolly-Andersen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epithelial cells represent the first barrier to viral infection and the site of viral entry and release is often intimately connected with viral spread and pathogenesis. The plasma membrane of epithelial cells is polarized into an apical and basolateral domain separated by tight junctions (TJs). LÄS MER