Sökning: "basic level"
Visar resultat 21 - 25 av 1124 avhandlingar innehållade orden basic level.
21. Identification and characterization of a novel cartilage gene product CILP, which is an early indicator of osteoarthritis
Sammanfattning : The aim of this work was to study alterations in the matrix composition of human articular cartilage in different stages of osteoarthritis and to isolate and characterize one of the proteins that is altered in the osteoarthritic process. The metabolism of articular cartilage in different stages of osteoarthritis including early asymptomatic OA was monitored in a culture system of metabolically labeled cartilage explants. LÄS MER
22. Microvascular plasticity and neurovascular coupling in the pharmacotherapy of Parkinson's disease
Sammanfattning : L-DOPA pharmacotherapy in Parkinson’s disease (PD) is associated with adverse effects occurring after a few years of treatment. Among these, dyskinesia (abnormal involuntary movements) is particularly common and potentially disabling. LÄS MER
23. Two worlds, one goal : A Clinician’s Perspective on Laboratory Analyses in Anticoagulant Treatment
Sammanfattning : Almost precisely a century ago, in the 1920s and 1930s, cattle bled to death in North America after being fed moldy hay containing sweet clover, the yellow Melilotus officinalis, and the white Melilotus albus. The toxic substance in the hay inhibiting blood coagulation was identified and named dicumarol. LÄS MER
24. The Role of Phosphodiesterase 3B in the Regulation of Insulin Secretion
Sammanfattning : Pancreatic beta-cell dysfunction and insulin resistance are the two hallmarks of type 2 diabetes. An early sign of beta-cell dysfunction is impaired nutrient-induced insulin release. Several insulin secretagogues act by increasing the formation of intracellular cAMP. LÄS MER
25. Design and Synthesis of Glycomimetics as Selective Galectin Inhibitors
Sammanfattning : In last couple of decades the field of glycobiology has developed rapidly due to the increased understanding of glycans’ abilities to encode biological information, which may have impact on biological event and disease, such as for example tumour growth and inflammation. This development has been accompanied by an increasing focus on drug discovery revolving around a category of carbohydrate-based drugs termed glycomimetics. LÄS MER