Sökning: "basic level"

Visar resultat 16 - 20 av 1127 avhandlingar innehållade orden basic level.

  1. 16. The role of phosphodiesterase 3B in energy metabolism

    Författare :Emilia Zmuda-Trzebiatowska; Signaltransduktionsforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; Physiology; Fysiologi; Medicin människa och djur ; glucose uptake; lipogenesis; adipocyte; Medicine human and vertebrates ; cAMP; PDE3B; insulin; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Energy metabolism at the level of any particular tissue is tightly regulated by hormones, neurotransmitters and cytokines in order to maintain overall energy homeostasis. Any dysfunctions in energy metabolism may lead to more or less severe consequences, with obesity and type 2 diabetes being the most prevalent ones. LÄS MER

  3. 17. Molecular biosignatures and gut-barrier alterations in inflammatory bowel diseases

    Författare :Luiza Moraes Holst; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammatory bowel diseases; ulcerative colitis; Crohn s disease; IBD; immunopathogenesis;

    Sammanfattning : Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders affecting the gastrointestinal tract. The multifactorial pathophysiology of IBD is commonly explained as an abnormal interplay between genetic, immune, environmental and microbial factors. LÄS MER

  4. 18. TNFalpha expression in monocytes/macrophages

    Författare :Karolina Andersson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; Protein kinase; Macrophage; TNF;

    Sammanfattning : The recognition of microbes or microbial products by leukocytes is a key event in innate immunity. Binding of microbial products to cell surface receptors on phagocytes induce a response that includes the production of inflammatory mediators. One such mediator is the cytokine tumour necrosis factor alpha (TNF). LÄS MER

  5. 19. Specific genetic modifications in the CNS - Cell specific expression and gene specific regulation

    Författare :Erika Elgstrand; CNS Genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease Gene therapy Cell specific GAD67 Rat Striatum Substantia nigra pars reticulata;

    Sammanfattning : Gene therapy is a promising therapeutic tool for many diseases of the CNS. Lentiviral vectors are particularly attractive since this vector type can transduce both dividing and non-dividing cells, have a relatively large cloning capacity, can sustain long-term transgene expression and have low immunogenicity. LÄS MER

  7. 20. An Associative Memory Trace in the Cerebellar Cortex

    Författare :Dan-Anders Jirenhed; Associativ inlärning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurofysiologi; neurophysiology; Neurologi; neuropsychology; Classical Conditioning; Cerebellum; Purkinje cell; Physiology; Fysiologi; Neurology;

    Sammanfattning : Classical conditioning of motor responses, e.g., the eyeblink response, depends on the cerebellum. In the theoretical works of David Marr (1969) and James Albus (1971), it was proposed that Purkinje cells in the cerebellar cortex learn to associate the neutral conditioned stimulus with the response. LÄS MER