Sökning: "basic fibroblast growth factor"

Visar resultat 1 - 5 av 55 avhandlingar innehållade orden basic fibroblast growth factor.

  1. 1. Regulation of fibroblast activity by keratinocytes, TGF-β and IL-1α studies in two- and three dimensional in vitro models

    Detta är en avhandling från Örebro : Örebro university

    Författare :Anita Koskela von Sydow; Örebro universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibroblast; Keratinocyte; TGF-β; IL-1α; coculture; fibrosis CTGF CNN 2; dermal; organotypic culture;

    Sammanfattning : Dysregulated wound healing is commonly associated with excessive fibrosis. Connective tissue growth factor (CTGF/CCN2) is characteristically overexpressed in fibrotic diseases and stimulated by transforming growth factor-β (TGF-β) in dermal fibroblasts. Reepithelialisation and epidermal wound coverage counteract excessive scar formation. LÄS MER

  2. 2. Posterior capsule opacification : An experimental study in vitro and in vivo

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Niklas Wallentin; Uppsala universitet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Posterior capsule opacification PCO ; after-cataract; lens epithelial cell; proliferation; aqueous humor AqH ; inflammation; growth factors; basic fibroblast growth factor bFGF ; transforming growth factor-β TGF-β ; extracapsular cataract extraction; corneal incision; rabbit; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : The clinical and economic significance of posterior capsule opacification (PCO) makes it an important public health problem. A better understanding of the pathogenesis in order to reduce/prevent PCO is needed. For this purpose an experimental model in the rabbit was used and further developed in thisthesis. LÄS MER

  3. 3. Vascular endothelial growth factor receptors in angiogenesis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Kui Huang; Uppsala universitet.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; endothelial cells; VEGF receptor; signal transduction; pertide; angiogenesis; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Angiogenesis is a process in which new capillaries sprout from preexisting blood vessels. Vascular endothelial growth factor (VEGF) promotes endothelial cell proliferation and migration and thereby stimulates angiogenesis. VEGF receptors (VEGFRs) have been implicated as key regulatory components in endothelial cells. LÄS MER

  4. 4. Fibroblast Growth Factor Receptor-1 Function in Vasculo- and Angiogenesis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Peetra Magnusson; Uppsala universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; FGF; FGFR-1; VEGFR-2; PDGFR-β; endothelial cells; embryonic stem cell; angiogenesis; hematopoiesis; Patologi; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi;

    Sammanfattning : During development of the mammalian embryo, spatial and temporal expression of fibroblast growth factors (FGFs) and their cognate receptors are vital in the regulation of a number of patterning processes. Inappropriate or decreased expression leads to severe malformations and even embryonic death. LÄS MER

  5. 5. Heparan Sulfate Regulation of Fibroblast Growth Factor (FGF) Receptor-1 Signal Transduction

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Lars Lundin; Uppsala universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; FGF; FGFR; dimerisation; signal transduction; heparan sulfate; proteoglycan; heparin; VEGF; embryonal stem cell; endothelial cell; differentiation; Patologi; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi;

    Sammanfattning : Fibroblast growth factors (FGFs) constitute a family (currently FGF-1 to FGF-23) of polypeptides that are essential in embryonal development and adult physiology, in animals from nematodes to humans. FGFs bind to four receptor tyrosine kinases, denoted FGFR-1 to FGFR-4. LÄS MER