Sökning: "basal ganglia"

Visar resultat 11 - 15 av 99 avhandlingar innehållade orden basal ganglia.

  1. 11. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement

    Författare :Nadine Schweizer; Åsa Wallén-Mackenzie; Dai Stephens; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subthalamic nucleus; STN; basal ganglia; locomotion; hyperlocomotion; rearing; ventral tegmental area; VTA; dopamine; glutamate; vesicular glutamate transporter 2; Vglut2; Parkinson s disease; deep brain stimulation; subpopulation; conditional knock-out; optogenetic; co-expression; in situ hybridization; self-administration; reward behavior; mouse genetics;

    Sammanfattning : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). LÄS MER

  3. 12. On the Causal Mechanisms of Stuttering

    Författare :Per A Alm; Lund Neurologi; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; stuttering; neurofysiologi; neuropsykologi; neurophysiology; Neurologi; dystonia; neuropsychology; Neurology; basal ganglia;

    Sammanfattning : Stuttering is one of the most common speech disorders. However, the etiology is poorly understood, and is likely to be heterogeneous. The aim of this thesis was to clarify causal mechanisms, focusing the brain. LÄS MER

  4. 13. Structure-Dynamics relationship in basalganglia: Implications for brain function

    Författare :Jyotika Bahuguna; Arvind Kumar; Jeanette Kotaleski; Nicholas Mallet; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Computational Modeling; Basal ganglia; network dynamics; Computer Science; Datalogi;

    Sammanfattning : In this thesis, I have used a combination of computational models such as mean field and spikingnetwork simulations to study various sub-circuits of basal ganglia. I first studied the striatum(chapter 2), which is the input nucleus of basal ganglia. LÄS MER

  5. 14. The subthalamic nucleus in motor and affective functions : An optogenetic in vivo-investigation

    Författare :Adriane Guillaumin; Åsa Wallén-Mackenzie; Konstantinos Meletis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Subthalamic nucleus; optogenetics; basal ganglia; locomotion; Parkinson s disease; aversion; Neuroscience; Neurovetenskap;

    Sammanfattning : The basal ganglia form a group of subcortical interconnected nuclei involved in motor, limbic and cognitive functions. According to the classical model of the basal ganglia, two main pathways exert opposing control over movement, one facilitating movement and the other suppressing movement. LÄS MER

  7. 15. Characterisation of inputs and outputs of striatal medium spiny neurons in health and disease

    Författare :Marko Filipović; Jeanette Hellgren Kotaleski; Arvind Kumar; Gilad Silberberg; Ad Aertsen; Andrew Sharott; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; basal ganglia; striatum; medium spiny neurons; subthalamic nucleus; globus pallidus; Parkinson s disease; in vivo; oscillations; spectral analysis; response variability; networks; simulations; modelling; Numerical Analysis; Numerisk analys; Computer Science; Datalogi; Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

    Sammanfattning : Striatal medium spiny neurons (MSNs) play a crucial role in various motor and cognitive functions. They are separated into those belonging to the direct pathway (dMSNs) and the indirect pathway (iMSNs) of the basal ganglia, depending on whether they express D1 or D2 type dopamine receptors, respectively. LÄS MER