Sökning: "bacteriophage"

Visar resultat 1 - 5 av 75 avhandlingar innehållade ordet bacteriophage.

1. 1. Structural Studies of Bacteriophage PRR1 and HIV-1 protease

   Författare :Magnus Persson; Lars Liljas; Kaspars Tars; Félix Rey; Uppsala universitet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRR1; HIV; Structural Biology; X-ray crystallography; PRR1; HIV-1 protease; NCS; crystallography; inhibitor; virus; bacteriophage; X-ray crystallography; Virology; Virologi; Molecular biology; Molekylärbiologi;

   Sammanfattning : Viruses are a diverse genera of organisms adapted to thrive in many different hosts from prokaryotic to eukaryotic.We present here the structure of bacteriophage PRR1 virus-like particle (VLP), belonging to Leviviridae family. Our structure reveals calcium ions in the VLP. LÄS MER

3. 2. Control of Quasi-Equivalence in Virus Capsids

   Författare :Charlotte Helgstrand; B. V. Venkataram Prasad; Uppsala universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; crystallography; bacteriophage; virus; RNA; capsid; quasi-equivalence; assembly; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Biotechnology; Molekylär bioteknik;

   Sammanfattning : Many T=3 plant and insect viruses use a molecular switch in form of order/disorder of a segment of the polypeptide chain to regulate the quasi-equivalent contacts. The structure of a mutant of the T=3 capsid of bacteriophage fr confirms that this virus and other members of the Leviviridae family lack a switch mechanism. LÄS MER

4. 3. Structure-Function Studies of Bacteriophage P2 Integrase and Cox protein

   Författare :Jesper Eriksson; Elisabeth Haggård; Karin Hammer; Stockholms universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Bacteriophage P2; site-specific recombination; integrase; transcriptional switch; Genetics; Genetik;

   Sammanfattning : Probably no group of organisms has been as important as bacteriophages when it comes to the understanding of fundamental biological processes like transcriptional control, DNA replication, site-specific recombination, e.t.c.The work presented in this thesis is a contribution towards the complete understanding of these organisms. LÄS MER

5. 4. Structural Studies of Large dsDNA Viruses using Single Particle Methods

   Författare :Hemanth Kumar Narayana Reddy; Martin Svenda; Sarah Butcher; Uppsala universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; PR772; phage; PRD1; Bacteriophage; coliphage; Melbournevirus; Cedratvirus; lurbo; Pithovirus; CryoEM; Single particle imaging; Coherent; Diffractive; Imaging; Soft X-ray; Microscopy; Microscope; GDVN; High resolution; XFEL; aerosol; Injection; electrospray; gas dynamic virtual nozzle; CDI; CXI; FEL; Chemistry with specialization in Biophysics; Kemi med inriktning mot biofysik;

   Sammanfattning : Structural studies of large biological assemblies pose a unique problem due to their size, complexity and heterogeneity. Conventional methods like x-ray crystallography, NMR, etc. are limited in their ability to address these issues. To overcome some of these limitations, single particle methods were used. LÄS MER

7. 5. Group I Introns and Homing Endonucleases in T-even-like Bacteriophages

   Författare :Linus Sandegren; Britt-Marie Sjöberg; Renée Schroeder; Stockholms universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Bacteriophage; Self-splicing introns; Homing endonucleases; Molecular biology; Molekylärbiologi;

   Sammanfattning : Homing endonucleases are rare-cutting enzymes that cleave DNA at a site near their own location, preferentially in alleles lacking the homing endonuclease gene (HEG). By cleaving HEG-less alleles the homing endonuclease can mediate the transfer of its own gene to the cleaved site via a process called homing, involving double strand break repair. LÄS MER