Sökning: "bacterial pathogenesis"

Visar resultat 21 - 25 av 146 avhandlingar innehållade orden bacterial pathogenesis.

  1. 21. Role of HAMLET and metabolism in treatment and pathogenesis of pneumococci

    Författare :Goutham Vansarla; Malmö Experimentell infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus pneumoniae; Antibiotic resistance; Alpha-lactalbumin; HAMLET; Biofilms; Bacterial metabolism; Immunomodulatory effects.;

    Sammanfattning : Antimicrobial resistance (AMR) is one of the principle public health problems in the 21st century, threatening the available treatment strategies for bacterial infections. Here, we present a human protein-lipid complex, HAMLET (human alpha-lactalbumin made lethal to tumor cells) purified from human milk as a potential therapeutic agent which has both tumoricidal and bactericidal activity. LÄS MER

  3. 22. Host responses and bacterial virulence factors in Neisseria infections

    Författare :Linda Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neisseria; CD46; LPS; antimicrobial peptide.;

    Sammanfattning : Neisseria meningitidis and Neisseria gonorrhoeae are human specific pathogens. N. meningitidis is a major cause of meningitis and sepsis, whilst N. gonorrhoeae causes many millions of cases of gonorrhea in the world every year. LÄS MER

  4. 23. Regulatory roles of sRNAs in pathogenesis of Vibrio cholerae

    Författare :Dharmesh Sabharwal; Sun Nyunt Wai; Bernt Eric Uhlin; Jörgen Johansson; Cynthia Sharma; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; sRNA; Biofilm; OmpT; RbmC; Vrp; VafA; mikrobiologi; Microbiology;

    Sammanfattning : The Gram-negative pathogen Vibrio cholerae uses variety of regulatory molecules to modulate expression of virulence factors. One important regulatory element of microorganisms is small non-coding RNAs (sRNAs), which control various cell functions such as expression of cell membrane proteins, mRNA decay and riboswitches. LÄS MER

  5. 24. Bacterial modulation of host glycosylation - in infection, biotechnology, and therapy

    Författare :Jonathan Sjögren; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgG; endoglycosidase; Streptococcus pyogenes; glycosylation; EndoS;

    Sammanfattning : A majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. LÄS MER

  7. 25. The female genital tract microbiota: composition, relation to innate immune factors, and effects of contraceptives

    Författare :Natalia Nikolaitchouk; Göteborgs universitet; []
    Nyckelord :bacterial vaginosis; checkerboard DNA-DNA hybridisation; cytokines; SLPI; Lactobacillus coleohominis; Lactobacillus iners; Actinomyces urogenitalis;

    Sammanfattning : Abnormal vaginal microbiota, as in bacterial vaginosis (BV), is associated with increased risk of obstetrical and gynaecologic complications and acquisition of sexually transmitted diseases. However, very little is known about the pathogenesis of BV. In BV, the normal vaginal Lactobacillus-dominated biota (LDB) is replaced by anaerobic bacteria. LÄS MER