Sökning: "bacterial evolution"

Visar resultat 21 - 25 av 135 avhandlingar innehållade orden bacterial evolution.

  1. 21. Mitochondrial and Eukaryotic Origins : A Phylogenetic Perspective

    Författare :Björn Brindefalk; Siv Andersson; James McInerney; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular evolution; Phylogenetics; Mitochondrial origin and Evolution; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Mitochondria are eukaryotic cellular organelles responsible for power-generation, believed to have come into existence by an endo-symbiontic event where a bacterial cell was incorporated by an un-specified "proto-eukaryote". Phylogenetic analysis have shown that the mitochondrial ancestor was most related to present-day alpha-proteobacteria, although the exact nature of the mitochondrial progenitor remains disputed. LÄS MER

  3. 22. Dynamics and Mechanisms of Adaptive Evolution in Bacteria

    Författare :Song Sun; Dan Andersson; Diarmaid Hughes; Josep Casadesús; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; adaptive evolution; mutation; genome rearrangements; antibiotic resistance; gene amplification; genome reduction; directed evolution; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : Determining the properties of mutations is fundamental to understanding the mechanisms of adaptive evolution. The major goal of this thesis is to investigate the mechanisms of bacterial adaptation to new environments using experimental evolution. LÄS MER

  4. 23. Identification, Characterization and Evolution of Membrane-bound Proteins

    Författare :Pär J. Höglund; Helgi B. Schiöth; Robert Fredriksson; Gert Vriend; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; G protein-coupled receptor; GPCR; Solute Carriers; SLC; Bioinformatics; Evolution; Rhodopsin; Adhesion; Phylogeny; Pharmacology; Farmakologi;

    Sammanfattning : Membrane proteins constitute approximately 30% of all genes in the human genome and two large families of membrane proteins are G protein-coupled receptors (GPCRs) and Solute Carriers (SLCs) with about 800 and 380 human genes, respectively.In Papers I, II and IV, we report 16 novel human Adhesion GPCRs found by searches in NCBI and Celera databases. LÄS MER

  5. 24. Methods and Applications in Comparative Bacterial Genomics

    Författare :Hans-Henrik Fuxelius; Siv Andersson; Björn Andersson; Uppsala universitet; []
    Nyckelord :Biology; Biologi;

    Sammanfattning : Comparative studies of bacterial genomes, now counting in the hundreds, generate massive amounts of information. In order to support a systematic and efficient approach to genomic analyses, a database driven system with graphic visualization of genomic properties was developed - GenComp. LÄS MER

  7. 25. Mechanisms of Antibiotic Resistance Evolution

    Författare :Michael Knopp; Dan Andersson; Anca Segall; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance evolution; Escherichia coli; Salmonella; porins; fitness; epistasis; strain-specificity; sub-MIC; de novo gene evolution;

    Sammanfattning : The continuing emergence and spread of antibiotic resistant bacteria are a threat to various applications in modern medicine and impose a strong economic burden on health systems. The development of new antibiotics is slow and cannot counterbalance the dissemination of resistant bacteria. LÄS MER