Sökning: "bacterial artificial chromosome"
Hittade 5 avhandlingar innehållade orden bacterial artificial chromosome.
1. Engineering short-chain carboxylic-acid metabolism in the model microorganism Escherichia coli
Sammanfattning : The ever-increasing concern about carbon dioxide emissions has created an urgent need to develop alternative methods to cheaply and renewably produce materials, chemicals and fuels. The biorefinery is uniquely suited to deliver these products from sustainable biomass. LÄS MER
2. Microfluidics and AI for single-cell microbiology
Sammanfattning : Most of the biological sciences deal with understanding the relationships between phenotypes and the underlying molecular mechanisms of organisms. This thesis is an engineering, computational, and experimental exercise in expanding the scope and scale of phenotype-genotype mapping techniques in single-cell microbiology using microscopy, microfluidics, and image processing. LÄS MER
3. Genetic studies of neuroblastoma with emphasis on the apoptotic pathway
Sammanfattning : Aim: The objective of this thesis was to find genes and chromosomal regions involved in neuroblastoma (NB) tumor progression. NB is a childhood tumor of the sympathetic nervous system that generally occurs spontaneously. LÄS MER
4. Refined diagnosis and prognosis in soft tissue sarcoma - genetic profiles, biomarkers and prognostic models
Sammanfattning : This work aimed at evaluate diagnosis and prognosis in soft tissue sarcoma (STS): In study I, 32K bacterial artificial chromosome (BAC) arrays and gene expression profiling were applied to 18 leiomyosarcomas and 31 undifferentiated pleomorphic sarcomas (UPS), with the aim of identifying molecular subtype signatures. Both the gains/losses profiles and the gene expression signatures revealed striking similarities between the two tumour types. LÄS MER
5. Genomic profiling of breast cancer by microarray-based technology and bioinformatics
Sammanfattning : Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to treatment. LÄS MER