Sökning: "b16 melanoma"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden b16 melanoma.

1. 1. Matrix metalloproteinases in natural killer cells. Expression of MMPs, IL-2 activation and killer cell interactions with Matrigel® and model tumours

   Författare :Per Albertsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protease; matrix metalloproteinase; killer cell; IL-2; Matrigel; B16 melanoma; tumour infiltration; invasion assay; zymography; Western blot; RT-PCR; light microscopy; fluorescence; electron microscopy;

   Sammanfattning : Introduction: IL-2 activated natural killer (A-NK) cells can recognize malignant cells and exert tumouricidal activities by multiple mechanisms that require close contact with the target cells. Upon adoptive transfer, some A-NK cells accumulate in tumours by migrating from the vascular bed to a position inside the malignant tissue, forming close contacts with target cells. LÄS MER

3. 2. Exploring novel roles of tumor pericytes

   Författare :Jong Wook Hong; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Tumor biology has been extensively studied over the last few decades, with a principal focus on how neoplastic cells obtain cellular immortality. A number of oncogenes and tumor suppressor genes have been uncovered that regulate cancerous transformation. LÄS MER

4. 3. Identifying molecular targets for cancer therapy

   Författare :W David Culp; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Within cancer research a molecular target is a specific molecular attribute in a cancer cell or tumor tissue that may play a role in promoting disease progression. There are many of these molecular attributes present in cancer biology and they represent events for therapeutic intervention. LÄS MER

5. 4. The effect of the tumor environment on the anti-tumor immune response

   Författare :W David Culp; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cancer immunotherapy is the process of stimulating the host's immune system to kill cancer cells, and it is being investigated as adjuvant therapy to traditional cancer treatments such as, surgery, radiation therapy and chemotherapy. Two advantages of using immunotherapy are that it employs additional tumor killing strategies, and it often results in modest side effects for patients. LÄS MER

7. 5. Exosomes : immunomodulators in cancer and therapy

   Författare :Stefanie Hiltbrunner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Exosomes are nano-sized membrane vesicles derived from the late endosomal compartment. They are capable of transferring proteins, lipids and RNA between cells. B cell and dendritic cell (DC)-derived exosomes express major histocompatibility complex (MHC) class I and II, as well as costimulatory molecules (CD80/86) and can initiate T cell responses. LÄS MER