Sökning: "azurophil granules"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden azurophil granules.

  1. 1. Bactericidal/Permeability-Increasing Protein (BPI) and Proteinase 3: Studies at the Transcriptional Level

    Författare :Katrien Pieters; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; azurophil granules; myelopoiesis; BPI; mouse ortholog; proteinase 3; transcriptional regulation; Wegener s Granulomatosis WG ; SNP; Medicine human and vertebrates ; extracellulära vätskor; Hematologi; extracellular fluids; Haematology; Medicin människa och djur ;

    Sammanfattning : In myelopoiesis, neutrophils and monocytes/macrophages are formed from a common myeloid precursor cell in the bone marow. During maturation of neutrophils, cytoplasmic granules are formed in the cells and the content of these granules is critical for the function of neutrophils in the first line of defense against invading microorganisms. LÄS MER

  3. 2. Sorting and processing of neutrophil granule proteins

    Författare :Elinor Bülow; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secretion; Haematology; extracellular fluids; Hematologi; extracellulära vätskor; cell-specific retention; chimeric; lysosome-related organelles; secretory pathway; propeptide of MPO; azurophil granules;

    Sammanfattning : The neutrophil granulocytes have a critical role in innate immunity in particular through phagocytosis of microorganisms. Their cytoplasmic granule subsets store digestive enzymes and antibiotic proteins that are released during this event. LÄS MER

  4. 3. Novel findings on cellular trafficking and targeting for granule storage of neutrophil elastase, a multifunctional effector molecule of innate immunity

    Författare :Linda Källquist; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic cell; CD63; neutrophil elastase; targeting; trafficking; intracellular sorting; neutrophil; azurophil granule;

    Sammanfattning : Neutrophil elastase (NE) has important roles in innate immunity, killing pathogens and controlling the immune response; but how NE is targeted to developing granules is not understood. Therefore, the aim of this thesis was to investigate the sorting of NE. LÄS MER

  5. 4. Membrane Proteins in Human Neutrophils - Identification and Characterization of Lipid Rafts in Subcellular Organelles

    Författare :Elisabeth Feuk-Lagerstedt; Göteborgs universitet; []
    Nyckelord :Human neutrophils; Subcellular organelles; Membrane proteins; Lipid rafts; DRMs;

    Sammanfattning : The human neutrophil is an important effector cell in acute inflammation and in the innate immune response against bacteria and fungi. When immune reactions occur in the tissue in response to antigen challenge, neutrophils are the first cells to enter the site of inflammation. LÄS MER

  7. 5. Transcriptional control of Bactericidal/permeability increasing protein (BPI) and cathepsin G in myeloid cells

    Författare :Andreas Lennartsson; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; extracellulära vätskor; Hematologi;

    Sammanfattning : The neutrophil store its effector proteins in several distinct types of cytoplasmic granules, developed sequentially during cell maturation. The different subtypes of granules have unique protein content and functional characteristics. The formation of each granule subtype coincides with the biosynthesis of its content. LÄS MER