Sökning: "aza-[2"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet aza-[2.

  1. 1. Novel Rearrangements of Vinylaziridines: Aza-[2,3]-Wittig Rearrangements and [1,5]-Hydrogen Shifts

    Detta är en avhandling från Organic Chemistry, Lund University

    Författare :Jens Åhman; [1996]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 6-tetrahydropyridines; 3; 2; substituted 1; indolizidine alkaloid synthesis; 5]-hydrogen shift; homodienyl-[1; 3]-Wittig rearrangement; vinylaziridine synthesis; aza-[2; N-alkylation of aziridines; allylic imines; 1-pyrrolines.; Organic chemistry; Organisk kemi;

    Sammanfattning : A route from epoxy alcohols to cis- and trans-trisubstituted vinylaziridines has been developed. The vinylaziridines have been used as substrates in the base induced aza-[2,3]-Wittig rearrangement to substituted 1,2,3,6-tetrahydropyridines. LÄS MER

  2. 2. Wnt/β-catenin Signaling and Epigenetic Deregulation in Breast Cancer and Parathyroid Tumours

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jessica Svedlund; Gunnar Westin; Göran Åkerström; Peyman Björklund; Ola Nilsson; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wnt signaling; parathyroid; epigenetic; Medicin; Medicine; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : The Wnt/β-catenin signaling pathway is often deregulated in cancer. Here we investigate Wnt/β-catenin signaling, aberrant accumulation of β-catenin, and epigenetic deregulation in breast cancer and parathyroid tumours. LÄS MER

  3. 3. Studies of epigenetic deregulation in parathyroid tumors and small intestinal neuroendocrine tumors

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Elham Barazeghi; Gunnar Westin; Peter Stålberg; Per Hellman; Christofer Juhlin; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epigenetics; 5hmC; TET1; TET2; parathyroid tumors; SI-NET; RRBS; PTPRM;

    Sammanfattning : Deregulation of the epigenome is associated with the initiation and progression of various types of human cancers. Here we investigated the level of 5-hydroxymethylcytosine (5hmC), expression and function of TET1 and TET2, and DNA methylation in parathyroid tumors and small intestinal neuroendocrine tumors (SI-NETs). LÄS MER

  4. 4. Genetic Aspects of Endocrine Tumorigenesis A Hunt for the Endocrine Neoplasia Gene

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Alberto Delgado Verdugo; Peyman Björklund; gunnar westin; Per Hellman; Filip Farnebo; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Exome sequencing; SDHAF2; epigenetics; methylation; methylation array; Sanger sequencing; pheochromocytoma; SI-NETs; carcinoid; oncology; endocrine surgery; parathyroid; Genetics; Genetik; Kirurgi; Surgery;

    Sammanfattning : Endocrine tumors arise from endocrine glands. Most endocrine tumors are benign but malignant variants exist. Several endocrine neoplasms display loss of parts of chromosome 11 or 18, produce hormones and responds poorly to conventional chemotherapeutics. The multiple endocrine neoplasia syndromes are mainly confined to endocrine tumors. LÄS MER

  5. 5. CANCER-RELATED GENE REGULATION MECHANISMS

    Detta är en avhandling från Department of Clinical Genetics, Lund University

    Författare :Srinivas Veerla; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cancer is a disease characterized by deregulation of cellular functions. The means by which these changes occur may differ among cancer types. However, common to all cancers are that they have changed the genetic programs that determine their characteristics. Genetic programs are mainly regulated by the action of transcription factors. LÄS MER