Sökning: "axonal growth"

Visar resultat 16 - 20 av 62 avhandlingar innehållade orden axonal growth.

  1. 16. Spinal cord repair strategies

    Författare :Henrich Cheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Spinal cord; injury; paraplegia; repair; regeneration; nerve graft; fibrin glue; aFGF; GDNF; gait; axonal tracing Henrich Cheng; 1996;

    Sammanfattning : Regeneration of long fiber tracts does not occur spontaneously in the adult mammalian brain or spinal cord. The present work is an attempt to develop a repair strategy that may overcome this lack of recovery and apply it to spinal cord injury. LÄS MER

  3. 17. Cell therapy for spinal cord injury, studies of motor and sensory systems

    Författare :Christoph Hofstetter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nervous system; spinal cord injury; pseudorabies virus; axonal tracing; functional MRI; stereology; Rho-kinases; transplantation; stem cells; neurogenin2; allodynia;

    Sammanfattning : Spinal cord injury represents a significant medical concern, affecting thousands of individuals each year. The majority of victims are young males harmed by traffic accidents, violence, and falls. Severe spinal cord injury interupts nerve fiber pathways connecting the brain and the rest of the body. LÄS MER

  4. 18. JNK/c-Jun Signaling and Peripheral Nerve Regeneration

    Författare :Charlotta Lindwall; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neuropsykologi; neurofysiologi; neurophysiology; Neurologi; neuropsychology; Neurology; Djurfysiologi; Animal physiology; JNK; signal transduction; nerve regeneration;

    Sammanfattning : The events associated with axonal injury in the peripheral nervous system (PNS) have been described in detail. However, the molecular mechanisms underlying the regenerative response, or neuronal cell death, following axonal injury are poorly understood. LÄS MER

  5. 19. Generation of functional neural progenitors for spinal cord transplantation

    Författare :Jan Hoeber; Elena Kozlova; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Regenerative Neurobiology; Stem cells; Sensory regeneration; Spinal cord injury; Neuroscience; Neurovetenskap;

    Sammanfattning : Dorsal root avulsion injuries result in permanent impairment of sensory functions due to the disconnection of the peripheral nervous system from the spinal cord. Strategies aiming for the functional reconnection of sensory neurons with their targets in the spinal cord dorsal horn need to overcome the axonal growth non-permissive glial scar and provide a growth promoting environment. LÄS MER

  7. 20. Peripheral nerve reconstruction. Studies on cellular and acellular iso-, allo- and xenografts

    Författare :Martin Kvist; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acellular nerve graft; costimulation blockade; FK506; immunosuppression; nerve graft; nerve defect; nerve regeneration; nerve injury; nerve extraction; allograft; xenograft;

    Sammanfattning : The best results after a nerve injury with a defect are achieved by a nerve reconstruction procedure using autologous nerve grafts. However, limitations include insufficient amount of suitable donor material and donor site morbidity. The aim of the present thesis was to study alternative nerve grafts, i.e. LÄS MER