Sökning: "auxiliary protein"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden auxiliary protein.

  1. 1. Synthesis of Novel Homoserine Analogues - Towards t he Development of Substrate-based Peptide Inhibitors of cAMP-dependent Protein Kinase

    Författare :Anna-Carin Carlsson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein kinases; protein kinase inhibitors; substrate-based kinase inhibitors; cAMP-dependent protein kinase; kemptide; homoserine; asymmetric -amino acid synthesis; glycine -anion equivalents; Schöllkopf’s bislactim ether; epoxidation; nucleophilic epoxide ring opening; microwave-assisted synthesis;

    Sammanfattning : Protein kinases are enzymes that via phosphorylation of proteins/peptides regulate most aspects of cell functions and physiology. The enzymes transfer a -phosphoryl group from ATP to hydroxyl groups of Ser, Thr and Tyr residues in their substrates. LÄS MER

  3. 2. Pulling Force Studies of Secretory Protein Translocation into the Endoplasmic Reticulum

    Författare :Theresa Kriegler; Tara Hessa; Patricia Clark; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Co-translational translocation; Xbp1 arrest peptide; Translocon-associated protein TRAP complex; Prion protein; Insulin; Biochemistry; biokemi;

    Sammanfattning : More than 30% of human genes encode secretory or membrane proteins. Most secretory proteins are targeted to the Endoplasmic reticulum (ER) membrane via cleavable N-terminal signal sequences either in a co- or post-translational manner. They enter or cross the membrane using a protein translocating channel (translocon). LÄS MER

  4. 3. Revealing Secrets of Synaptic Protein Interactions : A Biosensor based Strategy

    Författare :Christian Seeger; U Helena Danielson; Sarah Lummis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surface plasmon resonance; biosensor; AMPA receptor; GABAA receptor; ligand-gated ion channel; A-kinase anchoring protein; caldendrin; calmodulin; HIV; fragment based drug discovery; Biokemi; Biochemistry; Neuroscience; Neurovetenskap;

    Sammanfattning : Protein interactions are the basis of synaptic function, and studying these interactions on a molecular level is crucial for understanding basic brain function, as well as mechanisms underlying neurological disorders. In this thesis, kinetic and mechanistic characterization of synaptic protein interactions was performed by using surface plasmon resonance biosensor technology. LÄS MER

  5. 4. Functions of REP27 and the low molecular weight proteins PsbX and PsbW in repair and assembly of photosystem II

    Författare :Jose Gines Garcia Cerdan; Wolfgang Schröder; Eva-Mari Aro; Umeå universitet; []
    Nyckelord :Photosynthesis; photosystem II reaction center; PSII-LHCII supercomplex; antisense plant; T-DNA knockout plant; auxiliary protein; Biochemistry; biokemi;

    Sammanfattning :     Oxygenic photosynthesis is the major producer of both oxygen and organic compounds on earth and takes place in plants, green algae and cyanobacteria. The thylakoid membranes are the site of the photosynthetic light reactions that involve the concerted action of four major protein complexes known as photosystem II (PSII), cytochrome b6f complex, ATP synthase and photosystem I (PSI). LÄS MER

  7. 5. Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins

    Författare :Rebecca Josefson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aging; proteostasis; protein quality control; asymmetric inheritance; vesicle trafficking;

    Sammanfattning : Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging factors, e.g. damaged and aggregated proteins. LÄS MER