Sökning: "autonomic neurotransmission"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden autonomic neurotransmission.

1. 1. Studies on nitric oxide in autonomic neurotransmission

   Författare :Caroline Olgart; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :acetylcholine; autonomic neurotransmission; botulinum toxin; colon; guinea pig; ileum; intestine; nitric oxide; rat; tachykinin.;

   Sammanfattning : The aim of the present thesis was to study nitric oxide (NO) as a mediator in autonomic neurotransmission in the enteric nervous system, including studies on the mechanism for neuronal release of NO, as well as the effects of NO on intestinal smooth muscle and enteric neurones. Furthermore, the signal transduction pathway for the evoked effects of NO and nitrergic neurotransmission were investigated. LÄS MER

3. 2. Catecholaminergic neurotransmission in heart and brain : development of tracers for positron emission tomography

   Författare :Claus Oliver Langer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :PET; Radioligand; Catecholamine; Norepinephrine; Dopamine; Heart; Brain; Metaraminol; Dopamine D2 Receptor;

   Sammanfattning : The catecholamines norepinephrine and its biosynthetic precursor dopamine are two principal neurotransmitters in the human central nervous system (CNS). Moreover, norepinephrine is a major transmitter substance in the peripheral, autonomic nervous system. LÄS MER

4. 3. Neuronal release and function of nitric oxide in smooth muscle

   Författare :Henrik H Iversen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Autonomic neurotransmission; gastrointestinal tract; nitric oxide; nitric oxidesynthase; smooth muscle; urinary tract.;

   Sammanfattning : The aim of the present thesis was to study nitric oxide (NO) as an effector molecule in autonomic neurotransmission. The nitrergic transmitter was examined with regard to its pharmacological profile, stimuli of release, release pattern, and effects in gastrointestinal and urinary tract smooth muscle. LÄS MER

5. 4. On the role of nitric oxide in uterine secretion

   Författare :Birgitta Mörlin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Autonomic nerves; endometrial and cervical secretion; nitric oxide; guineapig.;

   Sammanfattning : Background: Uterine secretion is important in many different aspects of reproduction e.g. sperm transport and survival, fertilization, nourishment of the ovum and implantation. A cholinergic autonomic nervous secretory innervation has been established and modulation of the secretion by prostaglandins and NSAID drugs has been postulated. LÄS MER

7. 5. Nerve-induced release of nitric oxide in gastrointestinal and erectile tissue

   Författare :Katarina Hallén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Autonomic neurotransmission; cyclic guanosine monophosphate; guinea pig colon; neuronal nitric oxide synthase; nitric oxide; nitrite; phosphodiesterase; rabbit corpus cavernosum; smooth muscle; soluble guanylate cyclase;

   Sammanfattning : Nitric oxide (NO) is an important messenger of the autonomic nervous system, innervating the gastrointestinal and urogenital tracts among many other tissues. The aim of the present thesis was to study the nitrergic neurotransmission in enteric and erectile tissue with special emphasis on modulation of nitrergic neurotransmission by the soluble guanylate cyclase (sGC)/cyclic guanosine monophosphate (cGMP)-pathway. LÄS MER