Sökning: "autoimmune disease"

Visar resultat 21 - 25 av 619 avhandlingar innehållade orden autoimmune disease.

1. 21. Genetic Studies of Rheumatoid Arthritis using Animal Models

   Författare :Niklas Nordquist; William Dietrich; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Complex disease; autoimmune; rheumatoid arthritis; genetic; mapping; QTL; locus; linkage; animal model; rat; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Sammanfattning : Predisposition to autoimmune diseases such as, rheumatoid arthritis, diabetes, and multiple sclerosis, is caused by the effect of multiple genes and a strong influence from the environment. In this study, I have investigated genetic factors that confer susceptibility to rheumatoid arthritis in a rat model. LÄS MER

3. 22. Multiplex HLA-DR-DQ genotyping : for genetic epidemiology and clinical risk assessment

   Författare :Ewa Lavant; Malmö högskola; []
   Nyckelord :HLA-DRB1; HLA-DQB1; HLA-DQA1; PCR-SSP; type 1 diabetes; celiac disease; autoimmune disease; capillary gel electrophoresis; genotyping;

   Sammanfattning : The human leukocyte antigens (HLA) are highly polymorphic cell surface proteins encoded in the major histocompatibility complex (MHC) region on chromosome 6. The HLA system has been well known as transplantation antigens but the primary biological role of the HLA molecules is regulation of immune response by presenting peptide fragments to T-lymphocytes. LÄS MER

4. 23. Genetic Studies of Psoriasis and Psoriatic Arthritis

   Författare :Camilla Friberg; Göteborgs universitet; []
   Nyckelord :psoriasis; psoriatic arthritis; complex disease; autoimmune disease; linkage analysis; association analysis; PSOR5; 3q21; 5q31-32; SLC22A4; SLC22A5; CSTA; ZNF148; expression;

   Sammanfattning : Psoriasis and psoriatic arthritis are common chronic immune-mediated diseases of the skin and joints. Psoriasis affects approximately 2-3 % of the Caucasian population and about 30 % of all psoriasis patients develop psoriatic arthritis. LÄS MER

5. 24. Rational and Combinatorial Engineering of Affinity Proteins Towards Therapeutical Applications

   Författare :Johan Seijsing; Torbjörn Gräslund; Uhlén Mathias; Inger Sandlie; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neonatal Fc receptor; FcRn; affibody molecule; immunoglobulin G IgG ; serum albumin SA ; albumin binding domain ABD ; half-life extension; blocking; autoimmune disease; pH-dependence; GAD67; GAD-1; gene therapy; Parkinson’s disease; zinc finger based artificial transcription factor; Biotechnology; Bioteknologi;

   Sammanfattning : Protein engineering has had an immense impact on the development of biological drugs, including replacement therapies with engineered versions of insulin or factor VIII to treat diabetes or bleeding disorders, and monoclonal antibodies to treat cancer and various other malignancies. Now, with the next generation of treatment modalities coming up, including monoclonal reagents based on alternative scaffolds, gene and cell therapies, the importance of protein engineering to tailor-make these treatments is likely to increase further. LÄS MER

7. 25. Autoimmune Regulator Deficient Mice, an Animal Model of Autoimmune Polyendocrine Syndrome Type I

   Författare :Signe Hässler; Ola Winqvist; Olle Kämpe; Bertrand Huard; Uppsala universitet; []
   Nyckelord :Molecular medicine; autoimmune regulator; autoimmune polyendocrine syndrome type I; peripheral tolerance; antigen presenting cells; autoimmunity; danger signal; knockout mice; Molekylärmedicin;

   Sammanfattning : Autoimmune diseases develop when the immune system fails to distinguish self from non-self or when the immune system is hypersensitive to endogenous or exogenous danger signals, or when a tissue erroneously sends a danger signal to the immune system. The education of the immune system to distinguish self from non-self is mainly carried out in the thymus and gives rise to central tolerance, whereas the ability to sense a danger or a healthy tissue constitutes peripheral tolerance. LÄS MER