Sökning: "autoimmune arthritis"

Visar resultat 1 - 5 av 210 avhandlingar innehållade orden autoimmune arthritis.

  1. 1. B cells in Autoimmunity : Studies of Complement Receptor 1 & 2 and FcγRIIb in Autoimmune Arthritis

    Författare :Kajsa Prokopec; Sandra Kleinau; Anna Erdei; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cells; complement receptors; fc gamma receptor IIb; autoimmune arthritis; rheumatoid arthritis; Immunology; Immunologi;

    Sammanfattning : B cells are normally regulated to prevent activation against self-proteins through tolerance mechanisms.  However, occasionally there is a break in tolerance and B cells can become self-reactive, which might lead to the development of autoimmune disease. LÄS MER

  3. 2. Genetic Studies of Rheumatoid Arthritis using Animal Models

    Författare :Niklas Nordquist; William Dietrich; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Complex disease; autoimmune; rheumatoid arthritis; genetic; mapping; QTL; locus; linkage; animal model; rat; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Predisposition to autoimmune diseases such as, rheumatoid arthritis, diabetes, and multiple sclerosis, is caused by the effect of multiple genes and a strong influence from the environment. In this study, I have investigated genetic factors that confer susceptibility to rheumatoid arthritis in a rat model. LÄS MER

  4. 3. T lymphocytes in autoimmune arthritis : monoclonal antibody treatments in mouse and rat

    Författare :Tom J. Goldschmidt; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  5. 4. Function and Regulation of B-cell Subsets in Experimental Autoimmune Arthritis

    Författare :Anna-Karin E. Palm; Sandra Kleinau; Susanna Cardell; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; B cells; marginal zone; autoimmune arthritis; spleen; lymph node; antigen presentation; Fc gamma receptor IIb; complement receptors 1 and 2; mast cells; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Immunology;

    Sammanfattning : B lymphocytes play a significant role in autoimmune arthritis, with their function stretching beyond autoantibody production to cytokine secretion and presentation of autoantigen. However, the involvement and activation of different B-cell subset in the autoimmune response is not fully clear. LÄS MER

  7. 5. Analysis of effector pathways in arthritis

    Författare :Nandakumar Kutty Selva; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; Genetik; cytogenetics; Arthritis; mice; monoclonal antibody; collagen type II; Histology; histochemistry; cytochemistry; Histologi; tissue culture; cytokemi; histokemi; Genetics; vävnadskultur; serologi; cytogenetik; Immunology; serology;

    Sammanfattning : Rheumatoid arthritis (RA) is a multifactorial, polygenic autoimmune disease. For effective treatment and control of RA, understanding of disease pathways and identification of genes involved are essential. Animal models are efficient tools to identify such pathogenic mechanisms and genes underlying the disease process. LÄS MER