Sökning: "autocrine regulation of proliferation"
Visar resultat 1 - 5 av 18 avhandlingar innehållade orden autocrine regulation of proliferation.
- Detta är en avhandling från Göteborgs universitet
Sammanfattning : Mesenchymal stem cells (MSCs) play pivotal roles for bone regeneration by virtue of their osteogenic differentiation ability and immunomodulatory capacity. Recently, secretion of exosomes/extracellular vesicles (EVs) has been suggested as a new mechanism of MSC-based therapy. LÄS MER
- Detta är en avhandling från Sailaja Paruchuri, Entrance-78, 3rd floor, U-MAS, SE-20502, Malmo, Sweden
Sammanfattning : The pro-inflammatory mediator, Leukotriene D4 (LTD4) is a product of arachidonic acid cascade and has been implicated in asthma and inflammatory bowel diseases. Prolonged inflammatory conditions like ulcerative colitis increases the risk for the development of cancer and the factors that induce the chronic immune response remain uncertain. LÄS MER
- Detta är en avhandling från Department of Cardiology, Clinical sciences, Lund University
Sammanfattning : The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were shown in both mouse pancreatic islets and isolated β-cells using real-time PCR quantification. LÄS MER
- Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Women's and Children's Health
Sammanfattning : The aim of this thesis was to study B-cell function and the regulation of specific antibody (Abs) production in immunocompromised individuals. As models, we have studied children with acute lymphoblastic leukaemia (ALL) and patients with IRV- I infection. LÄS MER
5. Development of a protein-free fed-batch process for NS0 cells: studies on regulation of proliferationDetta är en avhandling från Stockholm : KTH
Sammanfattning : The overall objective of this study was to investigate how NS0 cell proliferation is regulated in protein-free media. The hypothesis was that during the adaptation to growth factor-free media, animal cell lines start to produce their own autocrine growth factors to support proliferation, and after some time in a culture the effects of these factors are lost which results in cessation of proliferation. LÄS MER