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Visar resultat 1 - 5 av 51 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Autoantigens in Addison's disease

    Författare :Ola Winqvist; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 2. Organ-specific autoantibodies in Addison's disease and autoimmune polyendocrine syndrome type I

    Författare :Annika Söderbergh; Uppsala universitet; []
    Nyckelord :Medical sciences; Addison s disease; APS I; Down syndrome; AIRE; autoantibodies; autoantigens; autoimmunity; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Assessment of autoantibodies is a valuable tool in the diagnostic procedure of autoimmune diseases. The aim of this study was to investigate the prevalence of different autoantibodies and their associations with disease manifestations in patients with Addison's disease and autoimmune polyendocrine syndrome type I (APS I). LÄS MER

  4. 3. Identification of autoantigens in multiple sclerosis

    Författare :Mattias Bronge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system in which cells from primarily the adaptive immune system infiltrate the brain and spinal cord, leading to inflammation and demyelination. Debuting primarily between 20-40 years of age and with a prevalence in Sweden of ~0. LÄS MER

  5. 4. Arthritogenic and immunogenic properties of modified autoantigens

    Författare :Karin Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Post-translational modifications; pH; chlorination; citrullination; CII; CIA; RA;

    Sammanfattning : Rheumatoid arthritis is a chronic inflammatory joint disorder with autoimmune features in which both genetic and environmental factors are potential contributors to the arthritogenic process. In this thesis work we aimed to increase the understanding of early pathogenic events underlying the development of this complex disease by investigating the arthritogenic and immunogenic properties of modified autoantigens in experimental settings as well as in RA patients. LÄS MER

  7. 5. Immunopeptidomics and autoantigens of interstitial lung diseases

    Författare :Emil Wiklundh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : We investigate Sarcoidosis and Idiopathic Pulmonary Fibrosis, IPF, to find markers for early fibrosis development. The aetiologies for both diseases are unknown and there is no specific treatment, moreover, there is a lack of diagnostic biomarkers for both diagnose and disease activity. LÄS MER