Sökning: "autoantibodies"
Visar resultat 6 - 10 av 297 avhandlingar innehållade ordet autoantibodies.
6. On the profiling of autoantibodies in psychiatric disorders
Sammanfattning : There is a great need to increase our understanding of diseases affecting the brain and their underlying pathogenic mechanisms. To address this need, the work presented in this thesis applied affinity based proteomic techniques to profile proteins, and to investigate protein profiles and the autoantibody repertoire in brain related disorders. LÄS MER
7. Autoantibodies as markers of beta-cell autoimmunity in children
Sammanfattning : Type 1 diabetes (T1D) is a chronic disease caused by destruction of the insulin producing beta-cells in the pancreas. The incidence of T1D has increased rapidly, especially in the Western world and among young children. LÄS MER
8. Studies of Autoantibodies in Systemic and Organ-Specific Autoimmune Disease
Sammanfattning : Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease, whereas autoimmune polyendocrine syndrome type 1 (APS1) is a rare autosomal disorder characterized by combinations of organ-specific autoimmune manifestations including hypoparathyroidism and intestinal dysfunction, and may serve as a model for organ-specific autoimmunity. Autoantibodies directed against proteins expressed in the affected tissues are found in both diseases. LÄS MER
9. Primary Sjögren's Syndrome: Studies of DNA damage responses and autoantibodies
Sammanfattning : Primary Sjögren’s syndrome (SS) is a chronic autoimmune disease of unknown etiology. The disease primarily involves lachrymal and salivary glands, leading to dryness of the eyes and mouth, but a wide spectrum of exocrine and non-exocrine disease manifestations may be seen. LÄS MER
10. Secretory Autoantibodies in Rheumatoid Arthritis
Sammanfattning : Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease in which autoantibodies, such as anti-citrullinated protein antibodies (ACPA), can be detected in the serum of patients. Autoantibodies may appear in the circulation years before clinical signs of joint inflammation occur, indicating that early immunological pathogenetic steps take place outside of the joints. LÄS MER
