Sökning: "auto antigens"
Visar resultat 1 - 5 av 18 avhandlingar innehållade orden auto antigens.
1. On the regulation of immune responses to dietary and self antigens
Sammanfattning : Regulatory mechanisms are necessary to avoid the misdirected aggressive immune responses responsible for the pathology seen in autoimmunity and allergy. Thymic-derived CD4+CD25+ regulatory T cells are indispensible for this regulation. We investigated if CD4+CD25+ Treg prevents auto-reactive responses in adult peripheral blood and cord blood. LÄS MER
2. Restricted antigen recognition in B cell chronic lymphocytic leukemia
Sammanfattning : Chronic lymphocytic leukemia (CLL) cells are considered to be derived from antigen-exposed B cells. To further explore the antigen-driven selection behind the leukemogenesis of CLL, we performed immunoglobulin (Ig) specificity screening of 7 CLL cell lines and 23 primary CLL clones from patient peripheral blood. LÄS MER
3. The blind spot : inflammatory pathways and specific antigens in clinical phenotypes of pulmonary sarcoidosis
Sammanfattning : Sarcoidosis is a granulomatous multisystem disorder of unknown aetiology, primarily manifesting in the lungs. The disease appears in two forms, which are mainly distinguished based on clinical criteria; Löfgren's syndrome (LS) presents with acute onset, usually fever, active inflammation and characteristic symptoms such as bilateral hilar lymphadenopathy (BHL), erythema nodosum and/or ankle arthritis, but is also associated with spontaneous resolution and a good prognosis. LÄS MER
4. IDO gene expression induction by DNA methylation inhibitors
Sammanfattning : The aim was to study the effect of DNA methylation of CpG motifs in cancer cells and immune cells by use of the DNA methyltransferas (DNMT) inhibitor zebularine. In cancer cells it is known that genes can be silenced by chromosomal deletion(s). It is also known that genes can be silenced by DNA methylation or expression of micro-RNA. LÄS MER
5. Multiplex HLA-DR-DQ genotyping : for genetic epidemiology and clinical risk assessment
Sammanfattning : The human leukocyte antigens (HLA) are highly polymorphic cell surface proteins encoded in the major histocompatibility complex (MHC) region on chromosome 6. The HLA system has been well known as transplantation antigens but the primary biological role of the HLA molecules is regulation of immune response by presenting peptide fragments to T-lymphocytes. LÄS MER