Sökning: "atorvastatin"

Visar resultat 11 - 15 av 18 avhandlingar innehållade ordet atorvastatin.

1. 11. Cholesterol metabolism in breast cancer: Prognostic factors and optimizing treatment

   Författare :Maria Inasu; Bröstcancer - prevention & intervention; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Statins; Cholesterol; menopausal status; endocrine treatment; disease recurrence;

   Sammanfattning : AbstractBreast cancer (BC) is the most common cancer among women in Sweden and worldwide. Adjuvant endocrine therapies are effective, yet 20-30% patients experience disease relapse. Altered cholesterol metabolism is an emerging hallmark of breast cancer proliferation and endocrine therapy resistance. LÄS MER

3. 12. Energy metabolism and angiogenesis in atherosclerosis and cancer

   Författare :Matias Ekstrand; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Energy metabolism; Hypoxia; Reactive oxygen species; Intussusceptive angiogenesis;

   Sammanfattning : Energy metabolism requires supply of glucose and oxygen. In atherosclerotic plaques and cancer tumors, there are local areas with mismatch in demand and supply of oxygen and nutrients. The resulting cellular energy imbalance may promote energy failure and stimulation of angiogenesis. LÄS MER

4. 13. Inflammatory proteins in the CNS-relation to Alzheimer's disease

   Författare :Catharina Lindberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Most neurodegenerative disorders are characterised by an inflammatory process in the brain. Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the elderly. Activated astrocytes and microglia surrounding the amyloid plaques represent evidence for neuroinflammation in the AD brain. LÄS MER

5. 14. Factors predicting progression of chronic kidney disease in IgA nephropathy

   Författare :Sigrid Lundberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Glomerulonephritis (GN) is the main cause of chronic kidney disease (CKD) in patients on renal replacement therapy, with IgA nephropathy (IgAN) being the most frequent single diagnosis. Patients with reduced kidney function and/or proteinuria have an increased risk of premature cardiovascular disease (CVD). LÄS MER

7. 15. Zebrafish models for large-scale genetic screens in dyslipidemia and atherosclerosis : Validation and application

   Författare :Manoj Kumar Bandaru; Marcel den Hoed; Anastasia Emmanouilidou; Ingelsson Erik; Shannon Fisher; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; dyslipidemia; atherosclerosis; genetic screens; high-cholesterol diet; APOE; APOB; LDLR; APOC2; PCSK9; LPAR2; GATAD2A; Medicinsk genetik; Medical Genetics;

   Sammanfattning : Hundreds of loci have been robustly associated with circulating lipids, atherosclerosis and coronary artery disease; but for most loci the causal genes and mechanisms remain uncharacterized. The overall aim of my thesis is to develop and validate novel in vivo model systems that are suitable for high-throughput, image-based genetic screens in coronary artery disease and related traits, and use these model systems to systematically characterize positional candidate genes. LÄS MER